摘要
与良性前列腺增生相关的下尿路症状(BPH-LUTS) 一个非常普遍的问题,对生活质量有着巨大的影响。研究表明,男性同时患上BPH-LUTS和勃起功能障碍(ED)有着很大的相关性。5型磷酸二酯酶抑制剂(PDE5i)在治疗ED时有着明显的疗效,最近有证据表明,该抑制剂也有利于改善男性下尿路症状。本文讨论了ED与LUTS共同的致病途径,使用PDE5i的科学依据以及单独使用PDE5i或 联合其他药物治疗LUTS的疗效。
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图形摘要
Current Drug Targets
Title:PDE-5 Inhibitors for BPH-Associated LUTS
Volume: 16 Issue: 11
Author(s): Philip Brousil, Majid Shabbir, E. Zacharakis and Arun Sahai
Affiliation:
关键词:
摘要: Lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH-LUTS) are a highly prevalent problem, and with considerable burden to quality of life. Evidence has emerged that a strong correlation exists in men suffering both BPH-LUTS and erectile dysfunction (ED). Phosphodiesterase type 5 inhibitors (PDE5i) have been shown to be highly effective in treating ED and more recently there is evidence that men with LUTS also benefit. In this review article we discuss the common pathogenic pathways of ED and LUTS, the scientific basis of PDE5i use, the efficacy of PDE5i in LUTS either as monotherapy or in combination with other established medications used in LUTS.
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Cite this article as:
Philip Brousil, Majid Shabbir, E. Zacharakis and Arun Sahai , PDE-5 Inhibitors for BPH-Associated LUTS, Current Drug Targets 2015; 16 (11) . https://dx.doi.org/10.2174/138945011611151013164756
DOI https://dx.doi.org/10.2174/138945011611151013164756 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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