摘要
目的:研究居住在新加坡的马来人意识障碍和老年痴呆症的发病率,同时检测中国人和马来人在发病率中的不同。 方法:样本(大于等于60岁)-从正在进行的多种族的新加坡老年痴呆症流行病学中的马来人成分中选出,使用局部验证简易智力测试和渐进的遗忘问卷筛选。随后,筛选阳性参与者进行详细的神经心理学和神经影像学评估。无痴呆型认知障碍(CIND)和痴呆型在公认标准上被诊断。 结果:包括总的966名马来人,102名为轻度CIND,135名调节性CIND,27名老年痴呆患者。所有年龄标准中任意意识障碍发病率为25.5%,包括2%的老年痴呆患者。任意意识障碍发病率中随年龄增长中60-64岁增加14.9%,大于等于80岁增加40.2%。女人较男人有更高的CIND和老年痴呆患病率。与早年中国EDIS出版的数据相比较,马来人有接近两倍的几率患任意一种意识障碍症(比值调整年龄,人口和心血管危险因素,载脂蛋白4载体:2.03,95%可信区间:1.48 - 2.77)结论:在老年马来人中,任意意识障碍的总患病率是25.5%。尽管有相似的和调节的已知危险因素,马来人意识障碍患病率依然高于中国人。很有必要做进一步的研究,解开可能导致这些种族意识障碍发生差异的其他因素
关键词: 意识障碍,老年痴呆症,马来人,发病率,风险因素,人口基础。
Current Alzheimer Research
Title:Prevalence of Cognitive Impairment and Dementia in Malays – Epidemiology of Dementia in Singapore Study
Volume: 14 Issue: 6
关键词: 意识障碍,老年痴呆症,马来人,发病率,风险因素,人口基础。
摘要: Objective: To study the prevalence of cognitive impairment and dementia in communitydwelling Malays from Singapore; and to examine differences in prevalence among Chinese and Malays.
Methods: Subjects (≥ 60 years) - drawn from the Malay component of the on-going multiethnic Epidemiology of Dementia in Singapore study - were screened using locally validated Abbreviated Mental Test and Progressive Forgetfulness Questionnaire. Subsequently, screen-positive participants underwent detailed neuropsychological assessments and neuroimaging. Cognitive impairment no dementia (CIND) and dementia were diagnosed based on accepted criteria. Results: A total of 966 Malay subjects were included, of whom 102 had CIND-mild, 135 CINDmoderate, and 27 dementia. The overall age-standardized prevalence of any cognitive impairment was 25.5%, including 2% of dementia. The prevalence of any cognitive impairment increased with age from 14·9% in those aged 60-64 years to 40.2% in age ≥80 years. Women had a higher prevalence of CIND and dementia than men. Compared to previously published data from EDIS on Chinese, Malay were nearly twice more likely to have any cognitive impairment (Odds ratios adjusted for age, demographic and cardiovascular risk factors, and ApoEε4 carrier: 2.03, 95% confidence interval: 1.48–2.77). Conclusion: Among elderly Malays, the overall prevalence of any cognitive impairment was 25.5%. Even with a similar protocol of recruitment and assessment and adjusting for known risk factors, the prevalence of cognitive impairment was higher in Malays compared to Chinese. Further research is needed to unravel other factors that may underlie these ethnic differences in the occurrence of cognitive impairment.Export Options
About this article
Cite this article as:
Prevalence of Cognitive Impairment and Dementia in Malays – Epidemiology of Dementia in Singapore Study, Current Alzheimer Research 2017; 14 (6) . https://dx.doi.org/10.2174/1567205012666151002123813
DOI https://dx.doi.org/10.2174/1567205012666151002123813 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Neuroprotection Abilities of Cytosolic Phospholipase A2 Inhibitors in Kainic acid-induced Neurodegeneration
Current Drug Targets - Cardiovascular & Hematological Disorders The Role of Nitric Oxide Synthase Inhibitors in Schizophrenia
Current Medicinal Chemistry Chronic Psychosocial Stress Exacerbates Impairment of Synaptic Plasticity in β-Amyloid Rat Model of Alzheimers Disease: Prevention by Nicotine
Current Alzheimer Research Pathogens and Chronic or Long-Term Neurologic Disorders
Cardiovascular & Hematological Disorders-Drug Targets Next Steps in Alzheimers Disease Research: Interaction between Epidemiology and Basic Science
Current Alzheimer Research Cardiovascular and Systemic Risk in Nonalcoholic Fatty Liver Disease - Atherosclerosis as a Major Player in the Natural Course of NAFLD
Current Pharmaceutical Design Current Progresses of Novel Natural Products and Their Derivatives/ Analogs as Anti-Alzheimer Candidates: an Update
Mini-Reviews in Medicinal Chemistry When Nutraceuticals Reinforce Drugs Side Effects: A Case Report
Current Drug Safety Editorial (Thematic Issue: Linkage of Neurodegenerative Disorders with Other Health Issues – Volume I)
CNS & Neurological Disorders - Drug Targets Getting to Know the Cast - Cellular Interactions and Signaling at the Neurovascular Unit
Current Pharmaceutical Design Human Cognition Assessment in Drug Research
Current Pharmaceutical Design Macrophage Differentiation to Foam Cells
Current Pharmaceutical Design Multivariate Analysis of Magnetic Resonance Imaging Signals of the Human Brain
Current Topics in Medicinal Chemistry Bidirectional Nature of Cardiovascular and Kidney Disease
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Anti-Aggressive, Brain Neurotransmitters and Receptor Binding Study of Fumaria indica in Rodents
Current Psychopharmacology Fish Oil Prevents Oxidative Stress and Exerts Sustained Antiamnesic Effect After Global Cerebral Ischemia
CNS & Neurological Disorders - Drug Targets 4-Hydroxynonenal in the Pathogenesis and Progression of Human Diseases
Current Medicinal Chemistry Mitochondrial Disorders in Adults
Current Molecular Medicine Effect of Resveratrol and Tiron on the Inactivation of Glyceraldehyde-3- phosphate Dehydrogenase Induced by Superoxide Anion Radical
Current Medicinal Chemistry Inhibition of Early Upstream Events in Prodromal Alzheimer’s Disease by Use of Targeted Antioxidants
Current Aging Science