Abstract
The treatment of cancer remains one of the most challenging problems for humanity. Boron neutron capture therapy (BNCT) is a binary approach for cancer treatment that is particularly attractive in treating high-grade gliomas and metastatic brain tumors. Among types of boron-containing molecules used as BNCT agents, boronated amino acids have received significant attention for their preferentially uptake by growing tumor cells. This review emphasizes the synthesis of boronated amino acids.
Keywords: isotopes, linear energy transfer (LET), 4-Dihydroxyborylphenylalanine, water-solubilizing functional group, melanoma, Bucherer-Strecker reaction
Anti-Cancer Agents in Medicinal Chemistry
Title: The Synthesis and Use of Boronated Amino Acids for Boron Neutron Capture Therapy
Volume: 6 Issue: 2
Author(s): George W. Kabalka and Min-Liang Yao
Affiliation:
Keywords: isotopes, linear energy transfer (LET), 4-Dihydroxyborylphenylalanine, water-solubilizing functional group, melanoma, Bucherer-Strecker reaction
Abstract: The treatment of cancer remains one of the most challenging problems for humanity. Boron neutron capture therapy (BNCT) is a binary approach for cancer treatment that is particularly attractive in treating high-grade gliomas and metastatic brain tumors. Among types of boron-containing molecules used as BNCT agents, boronated amino acids have received significant attention for their preferentially uptake by growing tumor cells. This review emphasizes the synthesis of boronated amino acids.
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Cite this article as:
Kabalka W. George and Yao Min-Liang, The Synthesis and Use of Boronated Amino Acids for Boron Neutron Capture Therapy, Anti-Cancer Agents in Medicinal Chemistry 2006; 6 (2) . https://dx.doi.org/10.2174/187152006776119144
DOI https://dx.doi.org/10.2174/187152006776119144 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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