摘要
多糖是从真菌到更复杂的生物,如鸟类和鲸鱼等各种来源获得的一类天然聚合物。多糖在制药和生物医学领域的应用已经成为由世界学术界众多研究的主题。本文主要关注于可应用于药物传递的纳米系统,并对多糖化学/物理修饰后形成接枝共聚物进行了讨论。因此,本文重点介绍了多糖基的共聚物特别是作为纳米载体在生物医学中的应用,还对海藻酸钙、纤维素、壳聚糖、葡聚糖、瓜尔胶、透明质酸、多糖和淀粉等多糖共聚物作为药物传递载体进行了讨论。
关键词: 多糖,嵌段共聚物,接枝共聚物,药物传递,纳米颗粒。
图形摘要
Current Drug Targets
Title:Polysaccharide based Copolymers as Supramolecular Systems in Biomedical Applications
Volume: 16 Issue: 14
Author(s): Regina Célia Monteiro de Paula, Judith Pessoa Andrade Feitosa and Haroldo César Beserra Paula
Affiliation:
关键词: 多糖,嵌段共聚物,接枝共聚物,药物传递,纳米颗粒。
摘要: Polysaccharides are natural polymers, obtained from a large variety of sources ranging from fungi to more complex organisms such as birds and whales. Their use for pharmaceutical and biomedical applications has been the subject of numerous researches by the world´s academia. Polysaccharide chemical/physical modifications leading to graft copolymers are discussed in this review, focusing on those nanosystems that are potential candidates for drug delivery applications. Therefore, this review focuses on the biomedical application of polysaccharide based copolymers, particularly as nanocarriers. Copolymer of polysaccharides such as alginate, cellulose, chitosan, dextran, guar, hyaluronic acid, pullulan and starch as drug delivery nanocarriers will be discussed.
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Cite this article as:
Regina Célia Monteiro de Paula, Judith Pessoa Andrade Feitosa and Haroldo César Beserra Paula , Polysaccharide based Copolymers as Supramolecular Systems in Biomedical Applications, Current Drug Targets 2015; 16 (14) . https://dx.doi.org/10.2174/1389450116666151001113537
DOI https://dx.doi.org/10.2174/1389450116666151001113537 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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