自我吞噬：将坐诊承诺转移到病人床边

Title:Autophagy : Moving Benchside Promises to Patient Bedsides

Volume: 15 Issue: 8

Author(s): Amine Belaid, Papa Diogop Ndiaye, Harilaos Filippakis, Jeremie Roux, Eric Rottinger, Yacine Graba, Patrick Brest, Paul Hofman and Baharia Mograbi

Affiliation:

关键词: 抗肿瘤药/药物作用/自噬靶向治疗，自噬成瘾/ KRAS/BRAF-driven癌症，肿瘤代谢，肿瘤抵抗力，肿瘤复发，肿瘤转移，肿瘤休眠，转化医学

摘要: Survival rates of patients with metastatic or recurrent cancers have remained virtually unchanged during the past 30 years. This fact makes the need for new therapeutic options even more urgent. An attractive option would be to target autophagy, an essential quality control process that degrades toxic aggregates, damaged organelles, and signaling proteins, and acts as a tumor suppressor pathway of tumor initiation. Conversely, other fascinating observations suggest that autophagy supports cancer progression, relapse, metastasis, dormancy and resistance to therapy. This review provides an overview of the contradictory roles that autophagy plays in cancer initiation and progression and discusses the promises and challenges of current strategies that target autophagy for cancer therapy.

Cite this article as:

Amine Belaid, Papa Diogop Ndiaye, Harilaos Filippakis, Jeremie Roux, Eric Rottinger, Yacine Graba, Patrick Brest, Paul Hofman and Baharia Mograbi , Autophagy : Moving Benchside Promises to Patient Bedsides, Current Cancer Drug Targets 2015; 15 (8) . https://dx.doi.org/10.2174/156800961508151001102452