Abstract
A systematic comparison with the Wild-Type (WT) of one-point mutants of bacteriophage T4 lysozyme was carried out using as difference markers the topological parameters of the protein contact networks corresponding to each crystallographic structure. The investigation concerned changes at the resolution level of single residue along the protein sequence. The results were correlated with (reported) changes in functional properties and (observed) changes in the information provided by the energy dissipation algorithm of the “Turbine” software simulation tool. The critical factor leading to significant difference among mutants and WT is in most cases associated to the sensitivity towards mutation of relatively short windows in the amino acidic sequence not necessarily contiguous to the active site.
Keywords: Bacteriophage T4, lysozyme, network analysis, protein structure.
Graphical Abstract
Current Protein & Peptide Science
Title:Functional heterogeneity as reflected by topological parameters in a classical protein molecular model: t4 phage lysozyme.
Volume: 17 Issue: 1
Author(s): Lisa Beatrice Caruso, Alessandro Giuliani and Alfredo Colosimo
Affiliation:
Keywords: Bacteriophage T4, lysozyme, network analysis, protein structure.
Abstract: A systematic comparison with the Wild-Type (WT) of one-point mutants of bacteriophage T4 lysozyme was carried out using as difference markers the topological parameters of the protein contact networks corresponding to each crystallographic structure. The investigation concerned changes at the resolution level of single residue along the protein sequence. The results were correlated with (reported) changes in functional properties and (observed) changes in the information provided by the energy dissipation algorithm of the “Turbine” software simulation tool. The critical factor leading to significant difference among mutants and WT is in most cases associated to the sensitivity towards mutation of relatively short windows in the amino acidic sequence not necessarily contiguous to the active site.
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Cite this article as:
Caruso Beatrice Lisa, Giuliani Alessandro and Colosimo Alfredo, Functional heterogeneity as reflected by topological parameters in a classical protein molecular model: t4 phage lysozyme., Current Protein & Peptide Science 2016; 17 (1) . https://dx.doi.org/10.2174/1389203716666150923103629
DOI https://dx.doi.org/10.2174/1389203716666150923103629 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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