Synthesis and Anti-thyroid Cancer Effect of Iodo-chrysin Derivatives

Title:Synthesis and Anti-thyroid Cancer Effect of Iodo-chrysin Derivatives

Volume: 12 Issue: 5

Author(s): Yun Wei, Qutong Zheng, Guotao Tang, Chen Song, Guan Wang, Yinxiang Zhang, Yan Xiao, Xianliang Zeng, Zongbao Wang, Jichang Xiao and Xing Zheng

Affiliation:

Keywords: Anti-thyroid cancer, activities, Baker-Venkataraman reaction, flavonoids, iodo-chrysin derivatives, MTT method.

Abstract: A novel series of iodo-chrysin derivatives with resorcinol as raw materials were synthesized according to Baker-Venkataraman reaction and their inhibitory activities in vitro against thyroid cancer cell lines (SW-579 and TT) were evaluated by the standard methyl thiazole tetrazolium (MTT) method. Biological test results showed that these derivatives possessed stronger anti-thyroid cancer activities than 5-FU. Compound 21 showed the strongest activity against SW-579 cell lines with IC50 value of 3.4μM and compound 10 showed the strongest activity against TT cell lines with IC50 value of 6.2μM, it was better than 5-FU (59.3μΜ, 18.4μM respectively).

Cite this article as:

Wei Yun, Zheng Qutong, Tang Guotao, Song Chen, Wang Guan, Zhang Yinxiang, Xiao Yan, Zeng Xianliang, Wang Zongbao, Xiao Jichang and Zheng Xing, Synthesis and Anti-thyroid Cancer Effect of Iodo-chrysin Derivatives, Medicinal Chemistry 2016; 12 (5) . https://dx.doi.org/10.2174/1573406411666150921111220