Abstract
Objective: To report and discuss a serious cutaneous adverse reaction in a child who was treated with acetaminophen (paracetamol). Case Summary: A five years old male child presented a pruriginous maculopapular rash and a “druginduced Stevens-Johnson syndrome/Toxic Epidermal Necrolysis” was suspected. Applying Spanish Pharmacovigilance System probability algorithm (modified Karch-Lasagna algorithm) for the suspected drugs (acetaminophen, ibuprofen and azithromycin), the causality of this adverse reaction was possible for acetaminophen and unlikely for the other two drugs. In this case it was recommended suspending and avoiding treatment with acetaminophen. This adverse reaction was reported to the Spanish Pharmacovigilance System (notification number: 10-600428). Discussion: Skin adverse reactions induced by drugs are uncommon but often serious and potentially fatal. There are few cases reports of “Stevens-Johnson syndrome/Toxic Epidermal Necrolysis” associated with acetaminophen in the literature. We present a documented case in a child. According to modified Karch-Lasagna algorithm, this case represents a possible adverse reaction. Conclusion: Hypersensitivity reactions with skin involvement are rarely associated with acetaminophen ingestion, but in a population such as the paediatric population, in which its use is widespread, the involvement of this drug should always be suspected if no other possible cause at sight.
Keywords: Acetaminophen, case report, drug adverse reaction, paracetamol, Stevens-Johnson syndrome, Toxic Epidermal Necrolysis.
Current Drug Safety
Title:A Case of Toxic Epidermal Necrolysis Secondary to Acetaminophen in a Child
Volume: 11 Issue: 1
Author(s): María Á. Pena, Sonia Pérez, Mª Concepción Zazo, Pedro J. Alcalá, Juan D. Cuello, Pedro Zapater and Roberto Reig
Affiliation:
Keywords: Acetaminophen, case report, drug adverse reaction, paracetamol, Stevens-Johnson syndrome, Toxic Epidermal Necrolysis.
Abstract: Objective: To report and discuss a serious cutaneous adverse reaction in a child who was treated with acetaminophen (paracetamol). Case Summary: A five years old male child presented a pruriginous maculopapular rash and a “druginduced Stevens-Johnson syndrome/Toxic Epidermal Necrolysis” was suspected. Applying Spanish Pharmacovigilance System probability algorithm (modified Karch-Lasagna algorithm) for the suspected drugs (acetaminophen, ibuprofen and azithromycin), the causality of this adverse reaction was possible for acetaminophen and unlikely for the other two drugs. In this case it was recommended suspending and avoiding treatment with acetaminophen. This adverse reaction was reported to the Spanish Pharmacovigilance System (notification number: 10-600428). Discussion: Skin adverse reactions induced by drugs are uncommon but often serious and potentially fatal. There are few cases reports of “Stevens-Johnson syndrome/Toxic Epidermal Necrolysis” associated with acetaminophen in the literature. We present a documented case in a child. According to modified Karch-Lasagna algorithm, this case represents a possible adverse reaction. Conclusion: Hypersensitivity reactions with skin involvement are rarely associated with acetaminophen ingestion, but in a population such as the paediatric population, in which its use is widespread, the involvement of this drug should always be suspected if no other possible cause at sight.
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Cite this article as:
Pena Á. María, Pérez Sonia, Zazo Concepción Mª, Alcalá J. Pedro, Cuello D. Juan, Zapater Pedro and Reig Roberto, A Case of Toxic Epidermal Necrolysis Secondary to Acetaminophen in a Child, Current Drug Safety 2016; 11 (1) . https://dx.doi.org/10.2174/1574886310666150921103852
DOI https://dx.doi.org/10.2174/1574886310666150921103852 |
Print ISSN 1574-8863 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3911 |
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