摘要
阿尔茨海默病(AD)是一种神经退行性疾病,由多种因素与疾病的进展联系在一起。目前市场上批准的药物不能治愈AD,反而只是提供症状缓解。多目标定向的配体的发展(MTDLs)是提高治疗质量的对像,polypharmacology复杂疾病是一个新兴的战略制药科学与多抽头延迟线开发交易的一个分支。在这个迷你审查中,我们总结和讨论,文献报道阿尔兹海默病进一步MTDLs设计不同的策略,我们已经讨论了电子技术和计算机辅助药物发现的在线资源的不同作用(CADD),设计或识别MTDLs反对阿尔兹海默病。
关键词: 阿尔兹海默病、CADD、多向药理学、多靶点导向配体。
图形摘要
Current Drug Targets
Title:CADD Modeling of Multi-Target Drugs Against Alzheimer's Disease
Volume: 18 Issue: 5
关键词: 阿尔兹海默病、CADD、多向药理学、多靶点导向配体。
摘要: Alzheimer’s disease (AD) is a neurodegenerative disorder that is described by multiple factors linked with the progression of the disease. The currently approved drugs in the market are not capable of curing AD; instead, they merely provide symptomatic relief. Development of multi-target directed ligands (MTDLs) is an emerging strategy for improving the quality of the treatment against complex diseases like AD. Polypharmacology is a branch of pharmaceutical sciences that deals with the MTDL development. In this mini-review, we have summarized and discussed different strategies that are reported in the literature to design MTDLs for AD. Further, we have discussed the role of different in silico techniques and online resources in computer-aided drug discovery (CADD), for designing or identifying MTDLs against AD.
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Cite this article as:
CADD Modeling of Multi-Target Drugs Against Alzheimer's Disease, Current Drug Targets 2017; 18 (5) . https://dx.doi.org/10.2174/1389450116666150907104855
DOI https://dx.doi.org/10.2174/1389450116666150907104855 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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