Abstract
Molecularly imprinted polymers (MIPs) are synthetic materials with tailor-made binding sites for a variety of chemical substances. However, the optimization of MIPs formulation is time-consuming and labourintensive since the interactions presenting in the pre-polymerisation mixture are complicated. Therefore, chemometrics, in which mathematical or statistical methods are used to analyze data, has been regarded as a useful tool to the optimization of MIP preparation. This article gave a mini review of the current status of the synthetic strategies in MIPs based on chemometric and computational methods in the past decade. The perspectives in the computation-based optimization for MIP preparation were also discussed.
Keywords: Molecularly imprinted polymers, design and evaluation, chemometrics, molecular dynamics.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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