Abstract
The focus of this review is on recent advancements in C–H activation having been reported in the last 2– 3 years. Both light-induced methods with the use of ruthenium photoredox catalysts and Ru-catalyzed processes accomplished through C–H activation are treated. Various C–C bond forming reactions—among others, alkylation and alkenylation of arenes, biaryl synthesis, annulations with multiple couplings as well as C–heteroatom couplings— are treated in subsections. Particular emphasis is given to the role of directing groups and related selectivity issues (regio-, chemo- and site-selectivity). Mechanistic issues are briefly highlighted to show key intermediates thereby shedding light on product forming process. This review may serve as a useful reference for chemists interested in recent developments of these rapidly developing fields by providing a selection from the plethora of new, invaluable information.
Keywords: C–C bond formation, C–H activation, C–heteroatom, coupling, directing groups, light-induced, multiple couplings, ruthenium.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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