摘要
作为肿瘤的重要特征,缺氧可以触发癌症的适应过程、诱导恶性表型发育和增强耐药性。以往的研究表明,exosomes 是这些过程中的关键因素。exosomes 是形成于内部网络泡状小体的小囊泡。这些小囊泡主要参与细胞间生物活性分子的转运。exosomes也是依赖于衍生供体细胞的细胞通信的中介,因此,受体细胞表型也会改变。此外,缺氧可显著刺激exosomes的分泌。例如,exosomes中的核酸和蛋白质是肿瘤微环境中的传输信号,有着多种功能,如诱发瘤内异质性、改变免疫反应、形成肿瘤相关成纤维细胞和促进血管生成和转移。此外,exosomes的含量与供体细胞相似。这些证据表明exosomes可以作为缺氧状态合适的生物标志物。因此,exosomes可用于协助诊断与微创手术预后。对exosomes的进一步研究将为癌症提供新的治疗方法。
关键词: exosomes,癌症、缺氧、肿瘤微环境、传输信号,生物标志物。
Current Medicinal Chemistry
Title:Exosomes: A Promising Factor Involved in Cancer Hypoxic Microenvironments
Volume: 22 Issue: 36
Author(s): Y. Yang, X. Yang, Y. Yang, H. Zhu, X. Chen, H. Zhang, F. Wang, Q. Qin, H. Cheng and X. Sun
Affiliation:
关键词: exosomes,癌症、缺氧、肿瘤微环境、传输信号,生物标志物。
摘要: As a significant tumor feature, hypoxia can trigger cancer adaptive processes, induce malignant phenotype development, and promote drug resistance. Previous studies demonstrated that exosomes are critical during these procedures. Exosomes are small vesicles formed in vesicular bodies in the endosomal network. These small vesicles are mainly involved in the transport of bioactive molecules between cells. Exosomes are also involved in the mediation of some cellular communications depending on derived donor cells; thus, recipient cells undergo phenotypic changes. Furthermore, hypoxia can remarkably stimulate exosomal secretion; for instance, nucleic acids and proteins as transmission signals in exosomes in a tumor microenvironment are involved in various functions, such as inducing intratumoral heterogeneity, altering immunological responses, producing cancer-associated fibroblasts, and promoting angiogenesis and metastasis. Moreover, exosome contents resemble those of a donor cell; this finding indicates that exosomes may also be regarded as suitable biomarkers of hypoxia status. Therefore, exosomes can be used to facilitate diagnosis and prognosis with minimal invasive procedures. Further studies on exosomes in cancer may provide new therapeutic strategies.
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Cite this article as:
Y. Yang, X. Yang, Y. Yang, H. Zhu, X. Chen, H. Zhang, F. Wang, Q. Qin, H. Cheng and X. Sun , Exosomes: A Promising Factor Involved in Cancer Hypoxic Microenvironments, Current Medicinal Chemistry 2015; 22 (36) . https://dx.doi.org/10.2174/0929867322666150825163318
DOI https://dx.doi.org/10.2174/0929867322666150825163318 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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