摘要
虽然治疗和预防艾滋病毒取得了巨大进展,艾滋病疫情在全球范围内持续肆虐,2013年报道有210万例HIV感染者并且有160万患者因艾滋病死亡。因缺乏有效的疫苗,我们迫切需要新的治疗和预防方法。在预防艾滋病病毒方面,预防和疫苗研究一直是重点,这涉及到HIV-1包膜蛋白gp120与细胞表面受体的相互作用,研究者希望通过对这些相互作用更好的理解而找到预防甚至治疗HIV-1感染的新方法。目前的研究主要关注于HIV传播的早期阶段和HIV首次感染宿主细胞的关键期。本文讨论了HIV-1包膜蛋白和与传播相关的细胞表面受体之间的相互作用,这为开发预防HIV感染的新方法提供了机遇。
关键词: HIV-1,gp12,传播, 信号传导,整合素,α4β7。
图形摘要
Current Drug Targets
Title:HIV-1 gp120: A Target for Therapeutics and Vaccine Design
Volume: 17 Issue: 1
Author(s): Claudia Cicala, Fatima Nawaz, Katija Jelicic, James Arthos and Anthony S. Fauci
Affiliation:
关键词: HIV-1,gp12,传播, 信号传导,整合素,α4β7。
摘要: Although extraordinary progress has been made in the treatment and prevention of HIV infection, the AIDS pandemic continues to rage globally with 2.1 million infections and 1.6 million AIDS-related deaths reported in 2013. Until an effective vaccine is developed, new strategies for treatment and prevention are needed. Regarding the prevention of HIV infection, a major focus of prevention research in general and vaccine research in particular involves the interaction of the HIV-1 envelope protein gp120 with cell-surface receptors, with the hope that a greater understanding of these interactions will lead to the development of novel strategies aimed at preventing and even treating HIV-1 infection. Particular attention has been directed toward gaining a more precise understanding of the early events in transmission focusing on that critical window of time when HIV first establishes infection in the host. Here we describe some of the recent findings involving HIV-1 envelope interactions with cell surface receptors that are relevant to transmission and which may represent new opportunities to develop strategies to prevent HIV infection.
Export Options
About this article
Cite this article as:
Claudia Cicala, Fatima Nawaz, Katija Jelicic, James Arthos and Anthony S. Fauci , HIV-1 gp120: A Target for Therapeutics and Vaccine Design, Current Drug Targets 2016; 17 (1) . https://dx.doi.org/10.2174/1389450116666150825120735
DOI https://dx.doi.org/10.2174/1389450116666150825120735 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Books
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Juvenile Systemic Lupus Erythematosus
Current Pediatric Reviews Cardioprotective Effects of Natural Products <i>via</i> the Nrf2 Signaling Pathway
Current Vascular Pharmacology Propofol and Systemic Inflammatory Response in Abdominal Aortic Surgery
Letters in Drug Design & Discovery Recognizing Severe Adverse Drug Reactions: Two Case Reports After Switching Therapies to the Same Generic Company
Current Drug Safety Combinatorial Application of Nucleic Acid-Based Agents Targeting Protein Kinases for Cancer Treatment
Current Pharmaceutical Design Drugs, Trials and Pathogenesis: Will Connecting these Help us Understand SLE?
Current Rheumatology Reviews Restoration of Antitumor Immunity Through Selective Inhibition of Myeloid Derived Suppressor Cells by Anticancer Therapies
Current Molecular Medicine Functional Regulation of Hepatic Cytochrome P450 Enzymes by Physicochemical Properties of Phospholipids in Biological Membranes
Current Protein & Peptide Science Erythropoietin: New Approaches to Improved Molecular Designs and Therapeutic Alternatives
Current Pharmaceutical Design The Kidney and the Sympathetic System: A Short Review
Current Clinical Pharmacology Current Status of Ethosomes and Elastic Liposomes in Dermal and Transdermal Drug Delivery
Current Pharmaceutical Design Implications of Somatic Mutations in the AML1/RUNX1 Gene in Myelodysplastic Syndrome (MDS): Future Molecular Therapeutic Directions for MDS
Current Cancer Drug Targets Estrogen Receptor-Positive and Estrogen Receptor-Negative Human Breast Cancer Cells: Regulation of Expression of Cancer-Related Genes by Estradiol and Tamoxifen
Current Signal Transduction Therapy Evolution of Exenatide as a Diabetes Therapeutic
Current Diabetes Reviews Alterations in the Peptidergic Regulation of Energy Balance in the Course of Aging
Current Protein & Peptide Science Pro-inflammatory Cytokines Modulate Glial Apolipoprotein E Secretion
Current Alzheimer Research What Can We Learn from Sarcopenia with Curarisation in the Context of Cancer Surgery? A Review of the Literature
Current Pharmaceutical Design Nitroso-Redox Balance and Modulation of Basal Myocardial Function: An Update from the Italian Society of Cardiovascular Research (SIRC)
Current Drug Targets The Clinical and Biological Relationship between Type II Diabetes Mellitus and Alzheimers Disease
Current Alzheimer Research Subject Index Volume 2
Current Pediatric Reviews