Abstract
For more than 30 years, lipid droplets (LDs) were considered as an inert bag of lipid for storage of energy-rich fat molecules. Following a paradigm shift almost a decade ago, LDs are presently considered an active subcellular organelle especially designed for assembling, storing and subsequently supplying lipids for generating energy and membrane synthesis (and in the case of hepatocytes for VLDL secretion). LDs also play a central role in many other cellular functions such as viral assembly and protein degradation. Here, we have explored the structural and functional changes that occur in hepatic and adipose tissue LDs following chronic ethanol consumption in relation to their role in the pathogenesis of alcoholic liver injury.
Keywords: Liver, alcohol, steatosis, lipid, triglycerides, adipose, lipid droplet, perilipin, phosphatidylcholine, phosphatidylethanolamine, lipases, ATGL, HSL, TGH, lipolysis, lipophagy, VLDL, rab, dynamin, Src, HCV, MiRs, betaine.
Graphical Abstract
Current Molecular Pharmacology
Title:Structure, Function and Metabolism of Hepatic and Adipose Tissue Lipid Droplets: Implications in Alcoholic Liver Disease
Volume: 10
Author(s): Sathish Kumar Natarajan, Karuna Rasineni, Murali Ganesan, Dan Feng, Benita L. McVicker, Mark A. McNiven, Natalia A. Osna, Justin L. Mott, Carol A. Casey and Kusum K. Kharbanda*
Affiliation:
- Veterans Affairs Nebraska Western Iowa Health Care System, Research Service (151), 4101 Woolworth Avenue, Omaha, Nebraska, 68105,United States
Keywords: Liver, alcohol, steatosis, lipid, triglycerides, adipose, lipid droplet, perilipin, phosphatidylcholine, phosphatidylethanolamine, lipases, ATGL, HSL, TGH, lipolysis, lipophagy, VLDL, rab, dynamin, Src, HCV, MiRs, betaine.
Abstract: For more than 30 years, lipid droplets (LDs) were considered as an inert bag of lipid for storage of energy-rich fat molecules. Following a paradigm shift almost a decade ago, LDs are presently considered an active subcellular organelle especially designed for assembling, storing and subsequently supplying lipids for generating energy and membrane synthesis (and in the case of hepatocytes for VLDL secretion). LDs also play a central role in many other cellular functions such as viral assembly and protein degradation. Here, we have explored the structural and functional changes that occur in hepatic and adipose tissue LDs following chronic ethanol consumption in relation to their role in the pathogenesis of alcoholic liver injury.
Export Options
About this article
Cite this article as:
Natarajan Kumar Sathish, Rasineni Karuna, Ganesan Murali, Feng Dan, McVicker L. Benita, McNiven A. Mark, Osna A. Natalia, Mott L. Justin, Casey A. Carol and Kharbanda K. Kusum*, Structure, Function and Metabolism of Hepatic and Adipose Tissue Lipid Droplets: Implications in Alcoholic Liver Disease, Current Molecular Pharmacology 2017; 10 (3) . https://dx.doi.org/10.2174/1874467208666150817111727
DOI https://dx.doi.org/10.2174/1874467208666150817111727 |
Print ISSN 1874-4672 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4702 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Biomedical Consequences of Alcohol Use Disorders in the HIV-Infected Host
Current HIV Research Interaction of Nerve Agent Antidotes with Cholinergic Systems
Current Medicinal Chemistry Brain Inflammation is a Common Feature of HIV-Infected Patients without HIV Encephalitis or Productive Brain Infection
Current HIV Research Targeting Protein Degradation in the Nervous System
Current Medicinal Chemistry - Central Nervous System Agents Role of Iodine, Selenium and Other Micronutrients in Thyroid Function and Disorders
Endocrine, Metabolic & Immune Disorders - Drug Targets Bidirectional Nature of Cardiovascular and Kidney Disease
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Critical Determinants of Cardiovascular Risk in Rheumatoid Arthritis
Current Pharmaceutical Design B Lymphocytes, Potent Antigen Presenting Cells for Preferential Expansion of Allo-Reactive FoxP3+ CD4 Regulatory T Cells
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Development of Nitrile-Based Peptidic Inhibitors of Cysteine Cathepsins
Current Topics in Medicinal Chemistry Antiviral Strategies: The Present and Beyond
Current Molecular Pharmacology Lessons Learned from HIV Treatment Interruption: Safety, Correlates of Immune Control, and Drug Sparing
Current HIV Research Nanoemulsion: A Novel Eon in Cancer Chemotherapy
Mini-Reviews in Medicinal Chemistry Treatment of Acute Leukaemias with Monoclonal Antibodies: Current Status and Future Prospects
Cardiovascular & Hematological Agents in Medicinal Chemistry Progress Towards Recombinant Anti-Infective Antibodies
Recent Patents on Anti-Infective Drug Discovery Innovative formulations for controlled drug delivery to the lungs and the technical and toxicological challenges to overcome<sup>#</sup>
Current Pharmaceutical Design The Role of Mitochondrial Function in Glutamate-Dependent Metabolism in Neuronal Cells
Current Pharmaceutical Design Chronic Alcohol Abuse and HIV Disease Progression: Studies with the Non-Human Primate Model
Current HIV Research Central and Peripheral Expression and Distribution of NUCB2/nesfatin-1
Current Pharmaceutical Design Withdrawal Notice: Therapeutic Options for Treatment of COVID-19: A Review from Repurposed Drugs to New Drug Targets
Current Drug Targets Targeting the Ubiquitin Proteasome System: Beyond Proteasome Inhibition
Current Pharmaceutical Design