摘要
癌症是一个全球性的重要问题,其发病率在全球范围内正在增加,而其治疗方案通常有限。因此,寻找具有肿瘤治疗潜力的新治疗靶点和新分子已成为当务之急。黄酮类化合物为多酚类化合物,可能是潜在的治疗药物。一些研究已经表明,这些化合物具有更大的抗癌潜力。在人类饮食中的黄酮类化合物中,槲皮素是最重要的药物之一。在过去的几十年中,已经描述了槲皮素的几种抗癌特性,如细胞信号转导、促凋亡、抗增殖和抗氧化作用及生长抑制。事实上,槲皮素具有不同的生物效应已众所周知,其抑制参与细胞增殖和信号转导通路中的多个酶。另一方面,也有研究报道,槲皮素结合化疗药物或放疗存在潜在的协同效应。事实上,一些旨在探讨这些在抗癌方面的联合治疗作用的研究已经发表,大多数前景可观。其实,众所周知,槲皮素不仅可作用于化疗增敏及放射增敏,也可用于化疗保护和防护,保护正常细胞免受化疗和放疗的副作用,其在抗癌治疗方面优势显著。因此,所有这些数据表明,槲皮素可能在抗癌治疗中发挥关键作用。在这种情况下,本文重点探讨黄酮类化合物和癌症之间的关系,并特别强调槲皮素的作用。
关键词: 癌,黄酮类,黄酮醇类,槲皮素,协同作用,治疗。
Current Medicinal Chemistry
Title:Quercetin in Cancer Treatment, Alone or in Combination with Conventional Therapeutics?
Volume: 22 Issue: 26
Author(s): Ana Filipa Brito, Marina Ribeiro, Ana Margarida Abrantes, Ana Salome Pires, Ricardo Jorge Teixo, Jose Guilherme Tralhao and Maria Filomena Botelho
Affiliation:
关键词: 癌,黄酮类,黄酮醇类,槲皮素,协同作用,治疗。
摘要: Cancer is a problem of global importance, since the incidence is increasing worldwide and therapeutic options are generally limited. Thus, it becomes imperative to find new therapeutic targets as well as new molecules with therapeutic potential for tumors. Flavonoids are polyphenolic compounds that may be potential therapeutic agents. Several studies have shown that these compounds have a higher anticancer potential. Among the flavonoids in the human diet, quercetin is one of the most important. In the last decades, several anticancer properties of quercetin have been described, such as cell signaling, pro-apoptotic, anti-proliferative and anti-oxidant effects, growth suppression. In fact, it is now well known that quercetin has diverse biological effects, inhibiting multiple enzymes involved in cell proliferation, as well as, in signal transduction pathways. On the other hand, there are also studies reporting potential synergistic effects when combined quercetin with chemotherapeutic agents or radiotherapy. In fact, several studies which aim to explore the anticancer potential of these combined treatments have already been published, the majority with promising results. Actually it is well known that quercetin can act on the chemosensitization and radiosensitization but also as chemoprotective and radioprotective, protecting normal cells of the side effects that results from chemotherapy and radiotherapy, which obviously provides notable advantages in their use in anticancer treatment. Thus, all these data indicate that quercetin may have a key role in anticancer treatment. In this context, this review is focused on the relationship between flavonoids and cancer, with special emphasis on the role of quercetin.
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Filipa Brito Ana, Ribeiro Marina, Margarida Abrantes Ana, Salome Pires Ana, Teixo Jorge Ricardo, Tralhao Guilherme Jose and Botelho Filomena Maria, Quercetin in Cancer Treatment, Alone or in Combination with Conventional Therapeutics?, Current Medicinal Chemistry 2015; 22 (26) . https://dx.doi.org/10.2174/0929867322666150812145435
DOI https://dx.doi.org/10.2174/0929867322666150812145435 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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