Abstract
Background: To carry out the hydrolysis of a bromomethylthiophenone to a hydroxymethylthiophenone, expensive silver triflate has to be used. We wanted to decrease the cost of this step.
Methods: Microwave heating in dimethyl sulfoxide and water was used to perform the above mentioned hydrolysis.
Results: The hydrolysis could be done in a scale up to one gram and the isolated yields were from 51 to 62%.
Conclusion: The best conditions for the hydrolysis were microwave irradiation in water and dimethyl sulfoxide at 100°C. Although the yields in the reaction were moderate and only around 70% of the starting material was accounted for, are the reaction conditions very simple and the reagents very cost effective.
Keywords: Bromomethyl- and hydroxymethylthiophenones, microwave assisted hydrolysis, simple reaction conditions, water/ DMSO.
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