Abstract
A rapid and efficient, one-pot, three-component, microwave-assisted synthesis of spiro[indoline-3,4'-quinoline] derivatives has been accomplished through three-component Knoevenagel/ Michael addition reaction of isatin, malononitrile and various amine derivative in very good to outstanding yields under CuCl2 catalyst. The main benefits of this protocol are simple work-up, trivial and eco-friendly reaction conditions. Biological characterization, including antibacterial was also evaluated.
Keywords: CuCl2, isatin, microwave-assisted synthesis, multi-component reactions, spiro compound.
Current Microwave Chemistry
Title:Rapid and Convenient CuCl2 Catalysed Microwave-Assisted Synthesis of Novel Spiro [indoline-3,4'-quinoline] Derivatives
Volume: 3 Issue: 2
Author(s): Mayuri A. Borad, Manoj N. Bhoi, Darshita M. Patel and Hitesh D. Patel
Affiliation:
Keywords: CuCl2, isatin, microwave-assisted synthesis, multi-component reactions, spiro compound.
Abstract: A rapid and efficient, one-pot, three-component, microwave-assisted synthesis of spiro[indoline-3,4'-quinoline] derivatives has been accomplished through three-component Knoevenagel/ Michael addition reaction of isatin, malononitrile and various amine derivative in very good to outstanding yields under CuCl2 catalyst. The main benefits of this protocol are simple work-up, trivial and eco-friendly reaction conditions. Biological characterization, including antibacterial was also evaluated.
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Cite this article as:
Borad A. Mayuri, Bhoi N. Manoj, Patel M. Darshita and Patel D. Hitesh, Rapid and Convenient CuCl2 Catalysed Microwave-Assisted Synthesis of Novel Spiro [indoline-3,4'-quinoline] Derivatives, Current Microwave Chemistry 2016; 3 (2) . https://dx.doi.org/10.2174/2213335602666150722232613
DOI https://dx.doi.org/10.2174/2213335602666150722232613 |
Print ISSN 2213-3356 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3364 |
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