摘要
目的:通过评估个体视网膜层的厚度,并利用谱域光学相干断层成像(SD-OCT)扫描技术和视网膜电图(ERG),研究眼睛自身免疫性视网膜病(AIR)的结构变化和功能丧失之间的相关性。 方法:6例血清诊断为眼睛自身免疫性视网膜病(AIR)患者的12只眼睛进行SD-OCT光栅扫描,并作出评价。视网膜层沿着一个水平扫描穿过的5毫米中央窝进行分割。视网膜层分解包括完整的视网膜厚度(FRT),视网膜色素上皮细胞和布鲁赫膜复合物(RPE + BM复杂),感光层(PRL),内核层(INL),结合神经节细胞和内网状层(GCL+),神经纤维层(NFL),结合的GCL+和NFL层(GCL+/NFL)。沿中央,鼻,颞区进行B细胞扫描,层厚度0.5毫米的变化增量作为评估标准,并将所记录的数据与没有已知眼病的51个受试者的51只眼睛的对应值进行比较。全场视网膜电图(ERGs)处理并由诊断和OCT结果进行解释。 结果:患者的平均年龄为59.5岁(33-83),其中男性4例(66.6%)。控制受试者人数为51人,平均年龄为51.5岁(40-75),其中男性25例(49%)。与没有已知眼病的眼睛相比,具有自身免疫性视网膜病的眼睛,其视网膜组织已被损坏。具体而言,FRT,RPE + BM复合体, PRL等具有不显著的统计学意义。 ERG结果证明,功能缺损和结构性损失密切相关。50%眼睛的中央光感受器(杆和视锥)功能障碍,75%眼睛的周边光感受器(杆和视锥)功能障碍。 结论:与没有已知眼病的眼睛相比,具有自身免疫性视网膜病的眼睛其视网膜组织已被损坏。最大的损坏似乎发生在视网膜色素(RPE)上皮和PRL。ERG结果与这些组织层的损坏非常相关。因此,治疗可以靶向保护视网膜的这些区域。
关键词: 自身免疫性视网膜病,视网膜,结构,功能,光学相干断层扫描,视网膜电图。
Current Molecular Medicine
Title:Assessment of Retinal Structural and Functional Characteristics in Eyes with Autoimmune Retinopathy
Volume: 15 Issue: 6
Author(s): Y.J. Sepah, M.A. Sadiq, M. Hassan, M. Hanout, M. Soliman, A. Agarwal, R. Afridi, S.G. Coupland and Q.D. Nguyen
Affiliation:
关键词: 自身免疫性视网膜病,视网膜,结构,功能,光学相干断层扫描,视网膜电图。
摘要: Purpose: To evaluate the thicknesses of individual retinal layers, and the correlation between structural changes and functional loss using spectral domain optical coherence tomography (SD-OCT) scans and electroretinograms (ERG), in eyes with autoimmune retinopathy (AIR).
Methods: SD-OCT raster scans of 12 eyes from 6 patients serologically diagnosed with AIR were evaluated. Retinal layers were segmented along a 5 mm horizontal scan passing through the fovea. Retinal layers analyzed include full retinal thickness (FRT), retinal pigment epithelium and Bruch’s membrane complex (RPE+BM complex), photoreceptor layer (PRL), inner nuclear layer (INL), combined ganglion cell and inner plexiform layers (GCL+), nerve fiber layer (NFL), and combined GCL+ and NFL layers (GCL+/NFL). Changes in the thicknesses of the layers were assessed in 0.5 mm increments along the B-scan in the central, nasal, and temporal regions. These recorded values were compared to corresponding values of 51 eyes from 51 subjects with no known ocular pathology. Full-field ERGs were obtained at corresponding visits and were interpreted by a grader masked to the diagnoses and OCT findings.
Results: The mean age of the patients was 59.5 years (range, 33-83), with 4 males (66.6%). Within the control population of 51 subjects, mean age was 51.5 years (range, 40-75), with 25 males (49%). Eyes with AIR showed a loss of retinal tissue compared to eyes with no known ocular pathology at the fovea. Specifically, the FRT, RPE+BM complex, and PRL exhibited thinning of statistically significance. ERG findings demonstrated a functional deficit which showed a good correlation with structural loss. Fifty (50) percent of eyes experienced central photoreceptor (rod and cone) dysfunction and 75% of eyes displayed peripheral photoreceptor (rod and cone) dysfunction.
Conclusions: Eyes with AIR show a loss of retinal tissue compared to eyes with no known ocular pathology. The greatest loss appears to occur in the RPE and PRL. ERG findings correlate strongly with the loss of tissue seen in these layers. Thus, therapeutic options may be targeted to preserve these regions of the retina.
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Y.J. Sepah, M.A. Sadiq, M. Hassan, M. Hanout, M. Soliman, A. Agarwal, R. Afridi, S.G. Coupland and Q.D. Nguyen , Assessment of Retinal Structural and Functional Characteristics in Eyes with Autoimmune Retinopathy, Current Molecular Medicine 2015; 15 (6) . https://dx.doi.org/10.2174/1566524015666150731104626
DOI https://dx.doi.org/10.2174/1566524015666150731104626 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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