Effects of Creatine in Skeletal Muscle Cells and in Myoblasts Differentiating Under Normal or Oxidatively Stressing Conditions

Title:Effects of Creatine in Skeletal Muscle Cells and in Myoblasts Differentiating Under Normal or Oxidatively Stressing Conditions

Volume: 16 Issue: 1

Author(s): Piero Sestili, Elena Barbieri and Vilberto Stocchi

Affiliation:

Keywords: Creatine, myogenesis, mitochondria, muscle diseases, skeletal muscle, supplementation.

Abstract: Creatine (Cr) - along with the Cr kinase (CK) system - plays a fundamental role in muscle biochemistry and physiology not limited to its ergogenic role. Indeed, Cr has been shown to exert pleiotropic effects, which promote protein accretion, muscle-specific protein synthesis, growth in cultured myogenic cells and favour the myogenic process either in normal or stressing conditions. This review focuses on the effects of Cr supplementation on cellular and mitochondrial biochemistry and function in the course of skeletal muscle differentiation, either in normal or oxidatively stressing conditions, and on the ensuing nutraceutical/therapeutic perspectives.

Cite this article as:

Sestili Piero, Barbieri Elena and Stocchi Vilberto, Effects of Creatine in Skeletal Muscle Cells and in Myoblasts Differentiating Under Normal or Oxidatively Stressing Conditions, Mini-Reviews in Medicinal Chemistry 2016; 16 (1) . https://dx.doi.org/10.2174/1389557515666150722102342