摘要
系统性红斑狼疮(SLE)是一种慢性自身免疫性结缔组织疾病,其特点是大量自身抗体的产生,但其病因复杂的,知之甚少。在过去的几十年中,一系列不同的平台作为自身抗体的特异性测定的筛选方法。蛋白组学是一个相对较新的高通量技术,其在自身抗体诊断中起着越来越重要的作用。在这篇文章中,我们回顾了系统性红斑狼疮中用于自身抗体分析的不同平台,突出自身抗原阵列的用途,即作为系统性红斑狼疮自身抗体探索的有力工具。
关键词: 系统性红斑狼疮,自身抗体,蛋白质组学,生物标志物,高通量分析。
Current Molecular Medicine
Title:Arraying Autoantibodies in SLE – Lessons Learned
Volume: 15 Issue: 5
Author(s): L. Wang, C. Mohan and Q.-Z. Li
Affiliation:
关键词: 系统性红斑狼疮,自身抗体,蛋白质组学,生物标志物,高通量分析。
摘要: Systemic lupus erythematosus (SLE) is a chronic autoimmune connective tissue disease characterized by the production of a large number of autoantibodies, but the etiology is complex and poorly understood. A range of different platforms have served as screening methods for the determination of autoantibody specificities over the past few decades. Proteomic microarray is a relatively new high-throughput technology which is playing an increasingly important role in autoantibody diagnostics. In this article, we review different platforms for assaying autoantibodies in SLE, and highlight the use of autoantigen arrays as powerful tools for autoantibody exploration in SLE.
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Cite this article as:
L. Wang, C. Mohan and Q.-Z. Li , Arraying Autoantibodies in SLE – Lessons Learned, Current Molecular Medicine 2015; 15 (5) . https://dx.doi.org/10.2174/1566524015666150630124649
DOI https://dx.doi.org/10.2174/1566524015666150630124649 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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