SLE中排列自身抗体–经验教训

Title:Arraying Autoantibodies in SLE – Lessons Learned

Volume: 15 Issue: 5

Author(s): L. Wang, C. Mohan and Q.-Z. Li

Affiliation:

关键词: 系统性红斑狼疮，自身抗体，蛋白质组学，生物标志物，高通量分析。

摘要: Systemic lupus erythematosus (SLE) is a chronic autoimmune connective tissue disease characterized by the production of a large number of autoantibodies, but the etiology is complex and poorly understood. A range of different platforms have served as screening methods for the determination of autoantibody specificities over the past few decades. Proteomic microarray is a relatively new high-throughput technology which is playing an increasingly important role in autoantibody diagnostics. In this article, we review different platforms for assaying autoantibodies in SLE, and highlight the use of autoantigen arrays as powerful tools for autoantibody exploration in SLE.

Cite this article as:

L. Wang, C. Mohan and Q.-Z. Li , Arraying Autoantibodies in SLE – Lessons Learned, Current Molecular Medicine 2015; 15 (5) . https://dx.doi.org/10.2174/1566524015666150630124649