摘要
细胞凋亡是肝脏疾病发病机制中的一个显著的特点。肝细胞凋亡的分子机制还不清楚。肝损伤诱导下调肝细胞核因子6(HNF6)是与细胞凋亡程度呈负相关。然而,肝细胞核因子-6增加可以减轻肝细胞凋亡和阻止肝脏疾病的进程。HNF6具有明显的调节肝细胞凋亡的机制。在不同类型肝损伤中肝细胞核因子-6的病理生理作用可能是抗凋亡和保护肝脏。故肝细胞核因子6的增强形态是肝脏疾病一种新型的治疗干预。
关键词: 干细胞凋亡,肝细胞核因子-6,肝损伤,核因子。
Current Molecular Medicine
Title:Pathophysiological Role of Hepatocyte Nuclear Factor 6 in Negative Regulation of Hepatic Apoptosis: A Novel Hypothesis
Volume: 15 Issue: 5
Author(s): K. Wang
Affiliation:
关键词: 干细胞凋亡,肝细胞核因子-6,肝损伤,核因子。
摘要: Apoptosis is a prominent characteristic in the pathogenesis of liver disease. The molecular mechanism of hepatic apoptosis is not well understood. Liver injury induces a downregulation of hepatocyte nuclear factor 6 (HNF6) that is negatively correlated with the degree of apoptosis. However, an enhancement of HNF6 can relieve hepatic apoptosis and impede the progression of liver disease. HNF6 has distinct mechanisms to modulate hepatic apoptosis. Pathophysiological role of HNF6 may be apoptosis-resistant and liver-protective during different types of liver injury. The enhancing modality of HNF6 is a novel therapeutic intervention for liver disease.
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Cite this article as:
K. Wang , Pathophysiological Role of Hepatocyte Nuclear Factor 6 in Negative Regulation of Hepatic Apoptosis: A Novel Hypothesis, Current Molecular Medicine 2015; 15 (5) . https://dx.doi.org/10.2174/1566524015666150630124142
DOI https://dx.doi.org/10.2174/1566524015666150630124142 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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