一种新假说：肝细胞核因子-6在肝细胞凋亡负调控中的病理生理作用

Title:Pathophysiological Role of Hepatocyte Nuclear Factor 6 in Negative Regulation of Hepatic Apoptosis: A Novel Hypothesis

Volume: 15 Issue: 5

Author(s): K. Wang

Affiliation:

关键词: 干细胞凋亡，肝细胞核因子-6，肝损伤，核因子。

摘要: Apoptosis is a prominent characteristic in the pathogenesis of liver disease. The molecular mechanism of hepatic apoptosis is not well understood. Liver injury induces a downregulation of hepatocyte nuclear factor 6 (HNF6) that is negatively correlated with the degree of apoptosis. However, an enhancement of HNF6 can relieve hepatic apoptosis and impede the progression of liver disease. HNF6 has distinct mechanisms to modulate hepatic apoptosis. Pathophysiological role of HNF6 may be apoptosis-resistant and liver-protective during different types of liver injury. The enhancing modality of HNF6 is a novel therapeutic intervention for liver disease.

Cite this article as:

K. Wang , Pathophysiological Role of Hepatocyte Nuclear Factor 6 in Negative Regulation of Hepatic Apoptosis: A Novel Hypothesis, Current Molecular Medicine 2015; 15 (5) . https://dx.doi.org/10.2174/1566524015666150630124142