摘要
肌卫星细胞是一种参与肌肉再生的单能性干细胞。然而,骨骼肌微环境发挥了超过干细胞功能的显著影响作用。骨骼肌利基的细胞内在复杂性在于纤维间的结缔组织包括运动神经元、肌腱、血管、免疫反应介质和间质细胞。所有这些细胞调节负责肌纤维再生刺激的转运。此外,一些干细胞类型在骨骼肌组织被发现,主要位于间质。大多数这些干细胞似乎直接导致肌原性的分化,尽管其中一些主要影响旁分泌作用。本文着重讨论已被用于治疗的成体干细胞,主要在慢性肌肉退化的动物模型中进行探讨。新文献识别由多能干细胞生成的其他肌原性祖细胞,作为潜在候选者用于治疗骨骼肌的退化。然而,成体干细胞仍然是未来比较研究的黄金标准。
关键词: 成体干细胞,肌肉萎缩,骨骼肌再生
Current Gene Therapy
Title:Adult Stem Cells and Skeletal Muscle Regeneration
Volume: 15 Issue: 4
Author(s): Domiziana Costamagna, Emanuele Berardi, Gabriele Ceccarelli and Maurilio Sampaolesi
Affiliation:
关键词: 成体干细胞,肌肉萎缩,骨骼肌再生
摘要: Satellite cells are unipotent stem cells involved in muscle regeneration. However, the skeletal muscle microenvironment exerts a dominant influence over stem cell function. The cell intrinsic complexity of the skeletal muscle niche located within the connective tissue between fibers includes motor neurons, tendons, blood vessels, immune response mediators and interstitial cells. All these cell types modulate the trafficking of stimuli responsible of muscle fiber regeneration. In addition, several stem cell types have been discovered in skeletal muscle tissue, mainly located in the interstitium. The majority of these stem cells appears to directly contribute to myogenic differentiation, although some of them are mainly implicated in paracrine effects. This review focuses on adult stem cells, which have been used for therapeutic purposes, mainly in animal models of chronic muscle degeneration. Emerging literature identifies other myogenic progenitors generated from pluripotent stem cells as potential candidates for the treatment of skeletal muscle degeneration. However, adult stem cells still represent the gold standard for future comparative studies.
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Domiziana Costamagna, Emanuele Berardi, Gabriele Ceccarelli and Maurilio Sampaolesi , Adult Stem Cells and Skeletal Muscle Regeneration, Current Gene Therapy 2015; 15 (4) . https://dx.doi.org/10.2174/1566523215666150630121024
DOI https://dx.doi.org/10.2174/1566523215666150630121024 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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