摘要
在全世界流行的糖尿病快速漫延,其中30%患者受糖尿病视网膜病变(DR)困扰。这表明其相关的视力疾病很可能将大幅的增加。这意味着我们要找到超越当前糖尿病治疗标准的,在疾病早期具有良好的新型治疗方法。近几十年,我们研究了一些新药剂的防止DR发生和发展及治愈DR的效力。其中一些取得了有限的成功,而其他展现了良好的前景。这篇DR非传统系统治疗的最新的关键综述是基于从1980年到2014年12月发表于MEDLINE的证据的。它讨论了许多治疗方法,特别描述了用于治疗DR的肾素-血管紧张素系统阻滞剂,非诺贝特和一水合羟苯磺酸钙的作用机理和临床研究。
关键词: 羟苯磺酸钙,糖尿病视网膜病变,fenofibrate,肾素-血管紧张素系统阻滞
Current Medicinal Chemistry
Title:Non-Traditional Systemic Treatments for Diabetic Retinopathy: An Evidence-Based Review
Volume: 22 Issue: 21
Author(s): Rafael Simo, Stefania Ballarini, Jose Cunha-Vaz, Linong Ji, Hermann Haller, Paul Zimmet and Tien Y Wong
Affiliation:
关键词: 羟苯磺酸钙,糖尿病视网膜病变,fenofibrate,肾素-血管紧张素系统阻滞
摘要: The rapid escalation in the global prevalence diabetes, with more than 30% being afflicted with diabetic retinopathy (DR), means it is likely that associated vision-threatening conditions will also rise substantially. This means that new therapeutic approaches need to be found that go beyond the current standards of diabetic care, and which are effective in the early stages of the disease. In recent decades several new pharmacological agents have been investigated for their effectiveness in preventing the appearance and progression of DR or in reversing DR; some with limited success while others appear promising. This up-to-date critical review of non-traditional systemic treatments for DR is based on the published evidence in MEDLINE spanning 1980-December 2014. It discusses a number of therapeutic options, paying particular attention to the mechanisms of action and the clinical evidence for the use of renin-angiotensin system blockade, fenofibrate and calcium dobesilate monohydrate in DR.
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Rafael Simo, Stefania Ballarini, Jose Cunha-Vaz, Linong Ji, Hermann Haller, Paul Zimmet and Tien Y Wong , Non-Traditional Systemic Treatments for Diabetic Retinopathy: An Evidence-Based Review, Current Medicinal Chemistry 2015; 22 (21) . https://dx.doi.org/10.2174/0929867322666150520095923
DOI https://dx.doi.org/10.2174/0929867322666150520095923 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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