摘要
阿尔茨海默病(AD)是最常见的痴呆症,导致人类死亡率和精神残疾率增加。目前治疗的广告主要依赖于使用乙酰胆碱酯酶抑制剂(AChEIs)或n -甲基- d -天门冬氨酸受体拮抗剂(NMDARs),他们只能缓解疾病的症状但不能阻止它的发展。然而,从中药中分离得到的许多生物活性成分对于阿尔茨海默病是有益的。在这篇综述中,我们总结在中药和生物活性成分缓解阿尔兹海默病的机械作用的最新信息。他们作为调节器的α-和β-分泌酶,并能抑制剂第二淀粉质(Aβ)聚合。其中一些抑制由于Aβ产生的神经细胞毒性和炎症。因此,这项工作已经证明在不久的将来,中药治疗阿尔兹海默病的可行性和从中药中筛选活性成分的可能性。
关键词: α-分泌酶,阿尔兹海默病,β-分泌酶,β-淀粉样蛋白,中药,治疗潜力
Current Medicinal Chemistry
Title:Therapeutic Effects of Herbal Chemicals in Traditional Chinese Medicine on Alzheimer’s Disease
Volume: 22 Issue: 19
Author(s): T.S. Cheung, T.H. Song, T.B. Ng, F.H. Wu, L.X. Lao, S.C.W. Tang, J.C.M. Ho, K.Y.B. Zhang and S.C.W. Sze
Affiliation:
关键词: α-分泌酶,阿尔兹海默病,β-分泌酶,β-淀粉样蛋白,中药,治疗潜力
摘要: Alzheimer’s disease (AD) is the most common type of dementia that leads to increasing death and mental disability among humans. Current therapy of AD mainly relies on the use of acetylcholinesterase inhibitors (AChEIs) or antagonists of N-methyl-D-aspartate receptors (NMDARs), which only relieve the symptoms of the disease but not halt its progression. Nevertheless, Traditional Chinese medicines (TCM) are highly prized as many bioactive components isolated from TCM are beneficial for treating AD. In this review, we summarize the latest information on TCM and the bioactive components according to their mechanistic role in alleviating AD. They act as modulators of α- and β-secretases, and inhibitors of betaamyloid (Aβ) aggregation. Some of them suppress Aβ-induced neuronal cytotoxicity and inflammation. Hence, this work has demonstrated the feasibility of applying TCM in AD therapy and the possibility of screening of constituents in TCM in the near future.
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T.S. Cheung, T.H. Song, T.B. Ng, F.H. Wu, L.X. Lao, S.C.W. Tang, J.C.M. Ho, K.Y.B. Zhang and S.C.W. Sze , Therapeutic Effects of Herbal Chemicals in Traditional Chinese Medicine on Alzheimer’s Disease, Current Medicinal Chemistry 2015; 22 (19) . https://dx.doi.org/10.2174/0929867322666150520095509
DOI https://dx.doi.org/10.2174/0929867322666150520095509 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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