摘要
MicroRNAs(miRNAs)是小的(19–25个核苷酸)转录后基因表达的调控非编码单链RNA。miRNA在脑中大量表达,在神经元分化、突触形成和可塑性的过程中,起着关键的作用。miRNAs参与一些神经系统疾病的病因也正在变得越来越明显。越来越多的证据表明,miRNA调控的信号通路在脑血管疾病如缺血性脑中风,蛛网膜下腔出血,血管性痴呆中有基因信号通路的表达调控能力。例如,miR-21通过动脉粥样硬化涉及缺血性脑中风的病理通路并对其抗凋亡的功能提供了神经保护作用,miR-497诱导了神经元死亡和miR-210在缺氧细胞中的上调。下调表达的miRNAs在应对缺血性中风时,使miRNA的使用可以作为一种有效的非侵入性的生物标志物。Antagomirs往往是有效的抗细胞凋亡因子并且可以诱导神经再生伴随缺血。此外,系统生物学的出现已经引入了新的计算工具来识别miRNA的靶基因之间的联系,并涉及了脑中风的病理及其治疗的转录因子。本文综述了miRNA在神经保护中的作用并且集中于miRNAs作为缺血性中风的核心要素的一个子集。
关键词: 生物标志物;缺血性脑中风;microRNA;神经保护;系统生物学。
图形摘要
Current Drug Targets
Title:ISCHEMIRs: Finding a Way Through the Obstructed Cerebral Arteries
Volume: 17 Issue: 7
Author(s): Sreekala S. Nampoothiri, Hari Vinayak Menon, Debashish Das, Rajanikant Golgodu Krishnamurthy
Affiliation:
关键词: 生物标志物;缺血性脑中风;microRNA;神经保护;系统生物学。
摘要: MicroRNAs (miRNAs) are small (19–25 nucleotides) non-coding single-stranded RNAs that control post-transcriptional gene expression. miRNAs are abundantly expressed in the brain, where they play key roles during neuronal differentiation, synaptogenesis, and plasticity. It is also becoming increasingly evident that miRNAs are involved in the etiology of several neurological disorders. Mounting evidence indicates that miRNAs have the ability to regulate the expression profiles of genes in signaling pathways associated with cerebrovascular diseases such as ischemic stroke, subarachnoid hemorrhage, and vascular dementia. For instance, miR-21 is involved in ischemic stroke pathology through atherosclerosis and provides neuroprotection by its anti-apoptotic features. miR-497 induces neuronal death and miR-210 is upregulated in hypoxic cells. Deregulated expression of miRNAs in response to ischemic stroke has enabled the use of miRNA as an efficient non-invasive biomarker. Antagomirs are often effective against neuronal apoptosis and can induce neuroregeneration following ischemia. Moreover, the advent of systems biology has introduced novel computational tools to identify the link between miRNAs, target genes and transcription factors involved in the stroke pathology and its treatment. This review describes the emerging role of miRNAs in neuroprotection and focuses on a subset of miRNAs that act as central players in ischemic stroke.
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Sreekala S. Nampoothiri, Hari Vinayak Menon, Debashish Das, Rajanikant Golgodu Krishnamurthy , ISCHEMIRs: Finding a Way Through the Obstructed Cerebral Arteries, Current Drug Targets 2016; 17 (7) . https://dx.doi.org/10.2174/1389450116666150518102404
DOI https://dx.doi.org/10.2174/1389450116666150518102404 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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