摘要
正常的控制条件下,热休克蛋白质在体内各种细胞中扮演重要的管家角色。热休克蛋白的许多不同的功能细胞取决于特定的热休克蛋白。每个蛋白根据其分子大小命名是有区别的。然而,除了在正常的细胞功能中的作用,作为在进化中被保留下来的残存蛋白质,热休克蛋白可能发挥更重要的作用,从而保护细胞免受各种各样的压力。细胞承受这些环境压力的能力是其保持适应力和可延续性的至关重要的能力。失去这种能力可能会导致病理状态。异常定位、结构或功能的热休克蛋白与许多疾病有关,包括心脏疾病。尤其是热休克蛋白HSP60和HSP70已经被确认在炎症和免疫反应中扮演重要的角色。最近被确定作为一种重要的炎症病理心脏疾病的危险因素。因此,这或许并不令人意外,热休克蛋白家族日益确认为是一种与炎症性心脏疾病包括动脉粥样硬化有关的重要细胞内途径。本文综述了证据来支持热休克蛋白在动脉粥样硬化疾病以及其他心血管疾病的作用和潜力。
关键词: 动脉粥样硬化,心血管疾病,细胞增生,热休克蛋白,免疫,炎症
Current Drug Targets
Title:Heat Shock Proteins: Mediators of Atherosclerotic Development
Volume: 16 Issue: 8
Author(s): Justin F. Deniset and Grant N. Pierce
Affiliation:
关键词: 动脉粥样硬化,心血管疾病,细胞增生,热休克蛋白,免疫,炎症
摘要: Heat shock proteins play important housekeeping roles in a variety of cells within the body during normal control conditions. The many different functions for heat shock proteins in the cell depend upon the specific heat shock protein involved. Each protein is nominally differentiated based upon its molecular size. However, in addition to their role in normal cell function, heat shock proteins may play an even more important role as pro-survival proteins conserved through evolution to protect the cell from a variety of stresses. The ability of a cell to withstand these environmental stresses is critical to its capacity to adapt and remain viable. Loss of this ability may lead to pathological states. Abnormal localization, structure or function of the heat shock proteins has been associated with many pathologies, including those involving heart disease. Heat shock proteins like HSP60 and HSP70 in particular have been identified as playing important roles in inflammation and immune reactions. Inflammation has been identified recently as an important pathological risk factor for heart disease. It is perhaps not surprising therefore, that heat shock protein family has been increasingly identified as an important intracellular pathway associated with inflammatory-mediated heart conditions including atherosclerosis. This paper reviews the evidence in support of a role for heat shock proteins in cardiovascular disease and the potential to target these proteins to alter the progression of atherosclerotic disease.
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Cite this article as:
Justin F. Deniset and Grant N. Pierce , Heat Shock Proteins: Mediators of Atherosclerotic Development, Current Drug Targets 2015; 16 (8) . https://dx.doi.org/10.2174/1389450116666150416115423
DOI https://dx.doi.org/10.2174/1389450116666150416115423 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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