肾脏疾病中新型炎症生物标记的重要性

Title:The Importance of Novel Inflammatory Biomarkers in Renal Disease

Volume: 22 Issue: 23

Author(s): S. Marinaki, C. Skalioti, Gerasimos Siasos, Athanasios G Papavassiliou, Dimitris Tousoulis and J.N. Boletis

Affiliation:

关键词: 急性肾损伤，生物标志物，慢性肾脏疾病，炎症，心血管死亡率，营养不良，蛋白质-能量消耗。

摘要: Kidney disease, whether acute or chronic, represents a major health hazard. Acute kidney injury (AKI) detection is based mainly on serum creatinine, which is considered to delay prompt diagnosis and management, thus increasing substantially patient morbidity and mortality and prolonged hospitalization. Several biomarkers have been evaluated as early prognostic markers of AKI. However, the vast majority of them are still far from being implicated into clinical practice. On the other hand, routine eGFR estimation and proteinuria monitoring have contributed to previous identification of chronic kidney disease (CKD). Hence, more sensitive and specific biomarkers are needed to enable us recognize individuals at increased risk for progression of CKD to end-stage renal disease (ESRD) and occurrence of cardiovascular complications. This review focuses on the most important novel inflammatory biomarkers that have emerged for early prediction, monitoring and management of kidney disease.

Cite this article as:

S. Marinaki, C. Skalioti, Gerasimos Siasos, Athanasios G Papavassiliou, Dimitris Tousoulis and J.N. Boletis , The Importance of Novel Inflammatory Biomarkers in Renal Disease, Current Medicinal Chemistry 2015; 22 (23) . https://dx.doi.org/10.2174/0929867322666150415124240