摘要
虽然有足够的手术治疗手段,但是晚期妇科恶性肿瘤(卵巢/子宫内膜恶性肿瘤)患者预后非常差。肿瘤预后改善主要取决于辅助治疗的强化。最近研究表明,女性卵巢/子宫内膜恶性肿瘤患者使用他汀类药物治疗后死亡率降低,这说明了确定他汀类药物抗癌特性的临床试验的必要性。体内和体外实验表明,细胞凋亡诱导剂和癌细胞生长、增殖、侵袭和转移抑制剂对恶性肿瘤存在潜在的化学预防作用。为了在晚期妇科恶性肿瘤手术治疗之后,确定指导他汀类药物与标准化疗/放疗方法相关的给药的理论基础,这一对肿瘤潜在影响的发现迫使我们去探讨他汀类药物抗肿瘤活性的所有可能的分子靶点。
关键词: 辅助治疗,晚期癌症,抗癌药物,妇科恶性肿瘤,药物的多效性作用,他汀类药物的使用。
图形摘要
Current Drug Targets
Title:Lipophilic Statins as Anticancer Agents: Molecular Targeted Actions and Proposal in Advanced Gynaecological Malignancies
Volume: 16 Issue: 10
Author(s): Salvatore Gizzo, Michela Quaranta, Giovanni Battista Nardelli and Marco Noventa
Affiliation:
关键词: 辅助治疗,晚期癌症,抗癌药物,妇科恶性肿瘤,药物的多效性作用,他汀类药物的使用。
摘要: Despite adequate surgery, women affected by advanced-stage gynaecological cancers (ovarian/ endometrial malignancies) carry an extremely poor prognosis; an improved oncological prognosis could largely depend upon the enhancement of adjuvant treatment. Recent data showed that, among women affected by endometrial/ovarian malignancies, a reduced cancer-related mortality was noted in statin-users compared to non-users, suggesting the need for clinical trials to define the anticancerproperties of statins. In vitro/in vivo evidences suggest a potential chemo-preventive effect through induction of cancer-cell apoptosis and inhibition of cancer-cell growth, proliferation, invasion, and metastasis. The potential oncological impact of this discovery compels us to investigate all possible molecular targets for anticancer activities of statins in order to identify a rationale in proposing their administration in association with standard chemotherapy/radiotherapy protocols after adequate surgical-treatment for advanced-stages gynaecological malignancies.
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Cite this article as:
Salvatore Gizzo, Michela Quaranta, Giovanni Battista Nardelli and Marco Noventa , Lipophilic Statins as Anticancer Agents: Molecular Targeted Actions and Proposal in Advanced Gynaecological Malignancies, Current Drug Targets 2015; 16 (10) . https://dx.doi.org/10.2174/1389450116666150330113239
DOI https://dx.doi.org/10.2174/1389450116666150330113239 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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