抗生素发现的复兴：关于发现治疗病菌药物的一些新策略

Title:Renaissance in Antibiotic Discovery: Some Novel Approaches for Finding Drugs to Treat Bad Bugs

Volume: 22 Issue: 18

Author(s): Bharat Gadakh and Arthur Van Aerschot

Affiliation:

关键词: 酰化的高丝氨酸内酯，抗生素，抗生素的发现，抗毒力策略，自诱导物，噬菌体，基因组方法，不增殖细菌，噬菌体疗法，群体感应，抵抗力，筛选策略，基于结构的药物设计

摘要: With the alarming resistance to currently used antibiotics, there is a serious worldwide threat to public health. Therefore, there is an urgent need to search for new antibiotics or new cellular targets which are essential for survival of the pathogens. However, during the past 50 years, only two new classes of antibiotics (oxazolidinone and lipopeptides) have reached the clinic. This suggests that the success rate in discovering new/novel antibiotics using conventional approaches is limited and that we must reconsider our antibiotic discovery approaches. While many new strategies are being pursued lately, this review primarily focuses only on a few of these novel/new approaches for antibiotic discovery. These include structure-based drug design (SBDD), the genomic approach, anti-virulence strategy, targeting nonmultiplying bacteria and the use of bacteriophages. In general, recent advancements in nuclear magnetic resonance, Xcrystallography, and genomic evolution have significant impact on antibacterial drug research. This review therefore aims to discuss recent strategies in searching new antibacterial agents making use of these technical novelties, their advantages, disadvantages and limitations.

Cite this article as:

Bharat Gadakh and Arthur Van Aerschot , Renaissance in Antibiotic Discovery: Some Novel Approaches for Finding Drugs to Treat Bad Bugs, Current Medicinal Chemistry 2015; 22 (18) . https://dx.doi.org/10.2174/0929867322666150319115828