MicroRNAs和前列腺癌对抗肿瘤药物的反应

Title:MicroRNAs and the Response of Prostate Cancer to Anti-Cancer Drugs

Volume: 17 Issue: 3

Author(s): Marzia Pennati, Marco Folini, Paolo Gandellini and Nadia Zaffaroni

Affiliation:

关键词: 抗肿瘤药物，microRNA，前列腺癌。

摘要: Despite considerable advances in early diagnosis, prostate cancer (PCa) remains the second leading cause of cancer-related deaths in men in western countries. In fact, although efficient therapies exist for early-stage disease, the treatment of advanced PCa remains unsuccessful mainly due to its poor responsiveness to anti-cancer agents. This evidence underlines the urgent need for the development of novel and more effective therapeutic approaches. In this context, the documented dysregulation of microRNAs (miRNAs) -which are short non-coding RNAs that regulate gene expression at post-transcriptional level- in PCa, together with their potential to simultaneously regulate multiple oncogenic/ tumor-suppressive pathways, has stimulated interest in defining a functional association between altered expression of specific miRNAs and the response of PCa to anti-cancer agents. The purpose of this review is to provide an overview on PCa-related miRNAs as potential novel therapeutic targets/tools, with a special focus on the role that they may play in conditioning the responsiveness of PCa to anti-cancer drugs.

Cite this article as:

Marzia Pennati, Marco Folini, Paolo Gandellini and Nadia Zaffaroni , MicroRNAs and the Response of Prostate Cancer to Anti-Cancer Drugs, Current Drug Targets 2016; 17 (3) . https://dx.doi.org/10.2174/1389450116666150316223341