Abstract
Mannich bases were selected for 2D QSAR study to derive meaningful relationship between the structural features and analgesic activity. Using the knowledge of important features a novel series was designed to obtain improved analgesic activity. A series of novel Mannich bases 1-(N-substituted amino)methyl]-2-substituted benzimidazole derivatives were synthesized and were screened for analgesic activity. Some of these compounds showed promising analgesic activity when compared with the standard drug diclofenac sodium.
Keywords: Analgesic activity, Mannich bases, N1-substituted benzimidazoles.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title:Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents
Volume: 14 Issue: 1
Author(s): Prasanna A. Datar and Saleel A. Limaye
Affiliation:
Keywords: Analgesic activity, Mannich bases, N1-substituted benzimidazoles.
Abstract: Mannich bases were selected for 2D QSAR study to derive meaningful relationship between the structural features and analgesic activity. Using the knowledge of important features a novel series was designed to obtain improved analgesic activity. A series of novel Mannich bases 1-(N-substituted amino)methyl]-2-substituted benzimidazole derivatives were synthesized and were screened for analgesic activity. Some of these compounds showed promising analgesic activity when compared with the standard drug diclofenac sodium.
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Cite this article as:
A. Datar Prasanna and A. Limaye Saleel, Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2015; 14 (1) . https://dx.doi.org/10.2174/1871523014666150312164625
DOI https://dx.doi.org/10.2174/1871523014666150312164625 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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