Abstract
Two methods of Lu-177 production are reviewed: irradiation of isotopically enriched Lu- 176 (direct way) and irradiation of ytterbium enriched with Yb-176 (indirect way). Based on neutronphysical calculations Lu-177 yield and specific activity were estimated for both methods. Lu-177 specific activity strongly depends on neutron flux density in the direct way, that is 75,000 Ci/g for 10- days irradiation in a neutron flux of 2.1015 cm-2s-1, and only 13,000 Ci/g after 30 days irradiation at neutron flux 1.1014 cm-2s-1. Irradiation of Yb-176 provides Lu-177 specific activity close to theoretical value (110,000 Ci/g). Neutron flux density effect Lu-177 yield, that is 530 Ci/g for 2.1015 cm-2s-1 neutron flux density after 30 days irradiation. A procedure of isolation and purification of Lu-177 from irradiated targets is described based on combination of galvanostatic extraction of ytterbium followed by cation-exchange chromatography from alfa-hydroxyisobutirate solutions on BioRad AG®50W-X8 resin.
Keywords: Lutetium-177, non-carrier added, high specific activity, reactor production, purification.
Graphical Abstract
Current Radiopharmaceuticals
Title:Production of No-Carrier Added Lutetium-177 by Irradiation of Enriched Ytterbium-176
Volume: 8 Issue: 2
Author(s): Valery A. Tarasov, Oleg I. Andreev, Evgeny G. Romanov, Rostislav A. Kuznetsov, Vladimir V. Kupriyanov and Ivan V. Tselishchev
Affiliation:
Keywords: Lutetium-177, non-carrier added, high specific activity, reactor production, purification.
Abstract: Two methods of Lu-177 production are reviewed: irradiation of isotopically enriched Lu- 176 (direct way) and irradiation of ytterbium enriched with Yb-176 (indirect way). Based on neutronphysical calculations Lu-177 yield and specific activity were estimated for both methods. Lu-177 specific activity strongly depends on neutron flux density in the direct way, that is 75,000 Ci/g for 10- days irradiation in a neutron flux of 2.1015 cm-2s-1, and only 13,000 Ci/g after 30 days irradiation at neutron flux 1.1014 cm-2s-1. Irradiation of Yb-176 provides Lu-177 specific activity close to theoretical value (110,000 Ci/g). Neutron flux density effect Lu-177 yield, that is 530 Ci/g for 2.1015 cm-2s-1 neutron flux density after 30 days irradiation. A procedure of isolation and purification of Lu-177 from irradiated targets is described based on combination of galvanostatic extraction of ytterbium followed by cation-exchange chromatography from alfa-hydroxyisobutirate solutions on BioRad AG®50W-X8 resin.
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Cite this article as:
A. Tarasov Valery, I. Andreev Oleg, G. Romanov Evgeny, A. Kuznetsov Rostislav, V. Kupriyanov Vladimir and V. Tselishchev Ivan, Production of No-Carrier Added Lutetium-177 by Irradiation of Enriched Ytterbium-176, Current Radiopharmaceuticals 2015; 8 (2) . https://dx.doi.org/10.2174/1874471008666150312160855
DOI https://dx.doi.org/10.2174/1874471008666150312160855 |
Print ISSN 1874-4710 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4729 |
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