摘要
真核细胞的细胞器官组织,代表蛋白质运输面临的挑战。相反在内质网、线粒体中蛋白转运出现后转译,蛋白质在细胞质核糖体中合成,然后再转运到细胞器。因为汤姆和蒂姆毛孔的直径对于通道折叠蛋白质来说太窄,所以假设多肽必须已经展开,才能够转运到细胞器。然而,有研究表明,线粒体可以展开外膜蛋白质本身。所以在这里,我们讨论折叠胞浆蛋白质对线粒体转运的影响。尽管线粒体展开蛋白的活性作用未排除在外,但是这一机制与实验证据不一致。因此, 在这里讨论线粒体蛋白转运的其他替代模型。分子约束规范这个过程的研究至关重要,因为它的失败会导致大量的病理情况。
关键词: 线粒体,转运,折叠,分子伴侣
Current Medicinal Chemistry
Title:Influence of Cytoplasmatic Folding on Mitochondrial Import
Volume: 22 Issue: 19
Author(s): H. Fraga and S. Ventura
Affiliation:
关键词: 线粒体,转运,折叠,分子伴侣
摘要: The eukaryotic cell, with its organelle organization, represents a challenge for protein traffic. Contrary to what occurs in the endoplasmic reticulum, mitochondrial protein import is proposed to occur postranslationaly, as proteins are synthesized in cytoplasmic ribosomes and only then imported to the organelle. Because the diameter of the Tom and Tim pores is too narrow for the passage of a folded protein, it is assumed that polypeptides must be already in an unfolded, import competent, state for organelle entry. However, it has been suggested that mitochondria might be able to actively unfold proteins itself at the outer membrane. Here we discuss the influence of cytoplasmatic protein folding on mitochondrial import. Despite the contribution of active mitochondrial unfolding to protein import is not excluded, this mechanism is inconsistent with a number of experimental evidences. Accordingly, other alternative models for mitochondrial import are here discussed. Understanding the molecular constraints regulating this process is of crucial importance, since its failure can lead to a number of pathological situations.
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Cite this article as:
H. Fraga and S. Ventura , Influence of Cytoplasmatic Folding on Mitochondrial Import, Current Medicinal Chemistry 2015; 22 (19) . https://dx.doi.org/10.2174/0929867322666150311153413
DOI https://dx.doi.org/10.2174/0929867322666150311153413 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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