循环肿瘤细胞在前列腺癌中的作用：治疗、临床及生物学意义

Title:Dormant Circulating Tumor Cells in Prostate Cancer: Therapeutic, Clinical and Biological Implications

Volume: 17 Issue: 6

Author(s): Maria J. Alvarez-Cubero, Fernando Vázquez-Alonso, Ignacio Puche-Sanz, F. Gabriel Ortega and M. Martin-Prieto, José L. Garcia-Puche, Manrique Pascual-Geler, José A. Lorente, José M. Cozar-Olmo, Maria J. Serrano

Affiliation:

关键词: ctcs，休眠，EMT，miRNA，前列腺癌。

摘要: Circulating Tumor Cells (CTCs) are a valuable prognostic factor in several solid tumors. By understanding the biological characteristics of CTCs we could better understand the biology of metastasis. CTCs usually adopt a dormant state that is believed to be a strategy to survive in extreme conditions. To enter a dormant state, CTCs undergo numerous phenotypic, genetic and functional mutations that significantly affect the efficacy of the therapies used to kill dormant CTCs. Hence, understanding the biological events involved in the dormancy process of CTCs would allow the identification of new therapeutic targets. Some experimental studies or preclinical models have explored these biological events, as well as the molecular factors that contribute to the maintenance of and release from dormancy. However, few studies have assessed the effects of anticancer therapies on dormant cells. This study reviews current the data currently available on cell dormancy mechanisms in prostate cancer, with a special focus on the functional, genetic and phenotypic plasticity of CTCs and their potential implications in the clinical and therapeutic management of prostate cancer.

Cite this article as:

Maria J. Alvarez-Cubero, Fernando Vázquez-Alonso, Ignacio Puche-Sanz, F. Gabriel Ortega and M. Martin-Prieto, José L. Garcia-Puche, Manrique Pascual-Geler, José A. Lorente, José M. Cozar-Olmo, Maria J. Serrano , Dormant Circulating Tumor Cells in Prostate Cancer: Therapeutic, Clinical and Biological Implications, Current Drug Targets 2016; 17 (6) . https://dx.doi.org/10.2174/1389450116666150309121346