摘要
循环肿瘤细胞(CTCs)是多种实体肿瘤的预后因子。通过了解CTCs的生物学特性,我们可以更好地了解其生物学的转移。CTCS通常处于休眠状态,这是其在极端条件下生存的方法。在进入休眠状态,ctcs经受许多表型、遗传和功能的突变,这会显着影响杀死休眠CTCs治疗方法的疗效。因此,了解有关CTCs的休眠过程的生物学知识将帮助我们鉴定新的治疗靶点。一些实验性的研究或临床前模型已经探索了这些维护和释放休眠的生物因素。然而,很少有研究评估癌疗法对休眠细胞的影响。本研究总结了目关于前列腺癌细胞休眠机制的数据,并侧重于CTCs的功能、遗传和表型可塑性以及及其前列腺癌临床治疗的潜在影响。
关键词: ctcs,休眠,EMT,miRNA,前列腺癌。
图形摘要
Current Drug Targets
Title:Dormant Circulating Tumor Cells in Prostate Cancer: Therapeutic, Clinical and Biological Implications
Volume: 17 Issue: 6
Author(s): Maria J. Alvarez-Cubero, Fernando Vázquez-Alonso, Ignacio Puche-Sanz, F. Gabriel Ortega and M. Martin-Prieto, José L. Garcia-Puche, Manrique Pascual-Geler, José A. Lorente, José M. Cozar-Olmo, Maria J. Serrano
Affiliation:
关键词: ctcs,休眠,EMT,miRNA,前列腺癌。
摘要: Circulating Tumor Cells (CTCs) are a valuable prognostic factor in several solid tumors. By understanding the biological characteristics of CTCs we could better understand the biology of metastasis. CTCs usually adopt a dormant state that is believed to be a strategy to survive in extreme conditions. To enter a dormant state, CTCs undergo numerous phenotypic, genetic and functional mutations that significantly affect the efficacy of the therapies used to kill dormant CTCs. Hence, understanding the biological events involved in the dormancy process of CTCs would allow the identification of new therapeutic targets. Some experimental studies or preclinical models have explored these biological events, as well as the molecular factors that contribute to the maintenance of and release from dormancy. However, few studies have assessed the effects of anticancer therapies on dormant cells. This study reviews current the data currently available on cell dormancy mechanisms in prostate cancer, with a special focus on the functional, genetic and phenotypic plasticity of CTCs and their potential implications in the clinical and therapeutic management of prostate cancer.
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Cite this article as:
Maria J. Alvarez-Cubero, Fernando Vázquez-Alonso, Ignacio Puche-Sanz, F. Gabriel Ortega and M. Martin-Prieto, José L. Garcia-Puche, Manrique Pascual-Geler, José A. Lorente, José M. Cozar-Olmo, Maria J. Serrano , Dormant Circulating Tumor Cells in Prostate Cancer: Therapeutic, Clinical and Biological Implications, Current Drug Targets 2016; 17 (6) . https://dx.doi.org/10.2174/1389450116666150309121346
DOI https://dx.doi.org/10.2174/1389450116666150309121346 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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