摘要
11C- PiB正电子发射断层摄影(PET)成像术经常被用于分析β淀粉样蛋白(Aβ)在生命个体中的沉积,但是其与组织学上确定了的Aβ的相关性还未检测。六名痴呆症患者接受了PiB-PET成像,并对他们的大脑进行神经病理上的分析(成像和死亡之间的平均间隔:816天;PiB阳性:阴性,3:3;男:女,3:3;平均年龄:84.0岁)。通过分析11个皮质区和10个皮层下灰质区的PiB的摄取值(报道称之为:标准摄入值比) ,并且与Aβ载量(Aβ阳性总面积的百分比)进行对比,Aβ载量通过使用抗Aβ11-28抗体进行免疫组化染色法后观察得出。 两名PiB-阳性受试者具有丰富的神经炎性斑块,并被诊断出患有阿尔茨海默病(AD),皮质区中的标准摄入值比和面积百分比与这些受试者紧密相关 (受试者1:r = 0.65,p = 0.03;受试者2:r = 0.80,p = 0.003)。 其他PiB-阳性受试者(受试者3)显示出局灶性的PiB摄取值。在受试者3和3名PiB-阴性受试者 (受试者4~6)中,局部性标准摄入值比与面积百分比或神经炎性斑块之间没有相关性。PiB的摄取值不与皮层下区中Aβ的沉积有关,大脑皮层中高PiB阳性表明大量Aβ沉积和神经炎性斑块的存在与阿尔茨海默病的病理变化有关。研究结果表明,高的皮质标准摄入值比是一个阿尔茨海默病的可靠标志。皮层下的PiB阳性还需更仔细地解释。
关键词: 阿尔茨海默症;淀粉样蛋白β;尸检;11 c-匹兹堡化合物B;断层显像;老年斑
Current Alzheimer Research
Title:Amyloid β Accumulation Assessed with 11C-Pittsburgh Compound B PET and Postmortem Neuropathology
Volume: 12 Issue: 3
Author(s): Hiroyuki Hatsuta, Masaki Takao, Kenji Ishii, Kiichi Ishiwata, Yuko Saito, Kazutomi Kanemaru, Tomio Arai, Tetsuya Suhara, Hitoshi Shimada, Hitoshi Shinotoh, Akira Tamaoka and Shigeo Murayama
Affiliation:
关键词: 阿尔茨海默症;淀粉样蛋白β;尸检;11 c-匹兹堡化合物B;断层显像;老年斑
摘要: 11C-Pittsburgh compound B (PiB) uptake in PET images is frequently used to analyze β amyloid (Aβ) deposition in living individuals, but its correlation with histologically determined Aβ has not been examined. Six individuals with dementia underwent PiB-PET imaging, and their brains were analyzed neuropathologically (mean interval between imaging and death: 816 days; PiB positive:negative, 3:3; male:female, 3:3; mean age: 84.0 years). PiB uptake (reported as standardized uptake value ratio [SUVR]) was analyzed in 11 cortical regions and 10 subcortical grey matter areas and compared with the Aβ load (% area [the percentage of total area positive for Aβ] and number of neuritic plaques) seen with immunohistochemical staining with an anti-Aβ 11-28 antibody. Two PiB-positive subjects had abundant neuritic plaques and were diagnosed with Alzheimer’s disease (AD). SUVR and % area were strongly correlated in the cortical regions of these subjects (subject 1: r = 0.65, p = 0.03; subject 2: r = 0.80, p = 0.003). The other PiBpositive subject (subject 3) showed focal PiB uptake. In subject 3 and the 3 PiB-negative subjects (subjects 4-6), there was no correlation between regional SUVR and % area or neuritic plaques. PiB uptake was not correlated with Aβ deposition in subcortical regions. High PiB positivity in the cerebral cortex suggests the presence of substantial Aβ deposition and neuritic plaques associated with the pathologic changes of AD. Our results suggest that high cortical SUVR is a reliable marker of AD. Subcortical PiB positivity must be interpreted more carefully.
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Hatsuta Hiroyuki, Takao Masaki, Ishii Kenji, Ishiwata Kiichi, Saito Yuko, Kanemaru Kazutomi, Arai Tomio, Suhara Tetsuya, Shimada Hitoshi, Shinotoh Hitoshi, Tamaoka Akira and Murayama Shigeo, Amyloid β Accumulation Assessed with 11C-Pittsburgh Compound B PET and Postmortem Neuropathology, Current Alzheimer Research 2015; 12 (3) . https://dx.doi.org/10.2174/1567205012666150302155930
DOI https://dx.doi.org/10.2174/1567205012666150302155930 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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