阿尔茨海默症解剖相关的神经症状

Title:Anatomical Correlates of the Neuropsychiatric Symptoms in Alzheimer’s Disease

Volume: 12 Issue: 3

Author(s): Xiaochen Hu, Dix Meiberth, Beate Newport, Frank Jessen and the Alzheimer’s Disease Neuroimaging Initiative

Affiliation:

关键词: 运动行为异常，激越，阿尔兹海默病，抑郁症，轻度认知障碍，神经精神症状，基于体素的形态学测量

摘要: The current study aimed to assess the relationship between the neuropsychiatric symptoms in Alzheimer’s disease (AD) and the regional grey matter (GM) volume using voxel based morphometry (VBM). Data of 85 AD patients, 208 subjects with mild cognitive impairment (MCI), and 131 healthy controls were selected from the Alzheimer’s Disease Neuroimaging Initiative. Individual VBM models across the entire sample for each items of the Neuropsychiatric Inventory Questionnaire as variables of interest were specified with four nuisance covariates, including age, sex, total intracranial volume (TIV), and Mini-Mental State Examination (MMSE) score. Agitation was related to the GM atrophy in the left inferior frontal/insula and bilateral retrosplenial cortices. Aberrant motor behavior (AMB) was related to the GM reductions in the right basal ganglia. The VBM models were recalculated by specifying three nuisance covariates (age, sex, TIV), and by excluding voxels related to AD severity by applying a MMSE mask. This procedure confirmed the first results, and additionally revealed associations between depression and GM atrophy in the left middle frontal cortex, between agitation and the GM atrophy in the left middle frontal cortex, and between AMB and GM reduction in the right inferior frontal cortex. Hierarchical multiple regression analyses using extracted mean GM value in these additional regions confirmed these associations. Finally, VBM analyses within a subgroup (85 AD patients and 41 MCI converters) largely confirmed the results. Our results suggest that specific patterns of GM atrophy within AD related neurodegeneration predispose to certain neuropsychiatric symptoms, suggesting distinct neurobiological mechanisms.

Cite this article as:

Xiaochen Hu, Dix Meiberth, Beate Newport, Frank Jessen and the Alzheimer’s Disease Neuroimaging Initiative , Anatomical Correlates of the Neuropsychiatric Symptoms in Alzheimer’s Disease, Current Alzheimer Research 2015; 12 (3) . https://dx.doi.org/10.2174/1567205012666150302154914