a-Blockers 和5ARIs联合治疗对良性前列腺增生（BPH）的影响

Title:The Impact of Combination Therapy with a-Blockers and 5ARIs on the Progression of BPH

Volume: 16 Issue: 11

Author(s): Petros Sountoulides and Stavros Gravas

Affiliation:

关键词: 5-α还原酶抑制剂，a-blockers，良性前列腺增生（BPH），良性前列腺梗阻（BPO），联合治疗，尿潴留。

摘要: Benign prostatic hyperplasia (BPH) can be a progressive disease for some men with significant impact on their quality of life due to worsening of symptoms, risk of acute urinary retention (AUR) and surgery. Certain clinical parameters such as age, prostate volume and PSA are able to predict those patients with BPH-associated LUTS that are at risk of disease progression. These patients will likely benefit most from medical therapy that provides symptom relief while at the same time may prevent disease progression. Studies have shown that a-blockers, although able to rapidly alleviate symptoms, have no effect on prostate volume, risk for AUR and BPH-related surgery. On the other hand 5ARIs have proven their efficacy in reducing prostate size, the risk of AUR and prostate surgery. Therefore combination therapy with an a-blocker and a 5ARI can be the mainstay of treatment for those patients at risk of BPH progression. Patients’ perspective and their needs and expectations from treatment are other crucial parameters to consider in order selecting the optimal management of BPH. Therefore physicians should take into consideration the drug properties and also the patients’ preferences before deciding on the optimal pharmacological treatment for BPH-associated LUTS.

Cite this article as:

Petros Sountoulides and Stavros Gravas , The Impact of Combination Therapy with a-Blockers and 5ARIs on the Progression of BPH, Current Drug Targets 2015; 16 (11) . https://dx.doi.org/10.2174/1389450116666150223164032