基于体素的形态学分析研究：伴有妄想症的轻度认知损伤和早期阿尔茨海默病人的灰质萎缩

Title:Grey Matter Atrophy in Mild Cognitive Impairment / Early Alzheimer Disease Associated with Delusions: A Voxel-Based Morphometry Study

Volume: 12 Issue: 2

Author(s): Windsor Kwan-Chun Ting, Corinne E. Fischer, Colleen P. Millikin, Zahinoor Ismail, Tiffany W. Chow and Tom A. Schweizer

Affiliation:

关键词: 阿尔茨海默病，妄想，执行控制，抑制，轻度认知障碍，基于体素的形态分析

摘要: Objectives: Grey matter atrophy in the right hemisphere has been shown to be more severe in dementia patients with delusions, suggesting a neuroanatomical localization that may be pertinent to impending neurodegeneration. Delusional symptoms may arise when atrophy in these areas reduces the regulatory functions of the right hemisphere, in tandem with asymmetric neuropathology in the left hemisphere. We hypothesized that delusional patients with either amnestic mild cognitive impairment (MCI) or early Alzheimer Disease (AD) would experience more pronounced grey matter atrophy in the right frontal lobe compared with matched patients without delusions. Methods: We used neuroimaging and clinical data obtained from the Alzheimer’s Disease Neuroimaging Initiative. A comparison group of twenty-nine nondelusional MCI/early AD participants were compared with twenty-nine delusional participants using voxel-based morphometry, matched at baseline by age, sex, education, and Mini-Mental State Exam score. All included participants were diagnosed with amnestic MCI at study baseline. Results: Fifteen voxel clusters of decreased grey matter in participants with delusions were detected. Prominent grey matter decrease was observed in the right precentral gyrus, right inferior frontal gyrus, right insula, and left middle occipital gyrus, areas that may be involved in control of thought and emotions. Conclusion: Greater right fronto-temporal grey matter atrophy was observed in MCI or early AD participants with delusions compared to matched patients without delusions. Consistent with our predictions, asymmetric grey matter atrophy in the right hemisphere may contribute to development of delusions through loss of executive inhibition.

Cite this article as:

Windsor Kwan-Chun Ting, Corinne E. Fischer, Colleen P. Millikin, Zahinoor Ismail, Tiffany W. Chow and Tom A. Schweizer , Grey Matter Atrophy in Mild Cognitive Impairment / Early Alzheimer Disease Associated with Delusions: A Voxel-Based Morphometry Study, Current Alzheimer Research 2015; 12 (2) . https://dx.doi.org/10.2174/1567205012666150204130456