Synthesis and In Vitro Evaluation of Furan-Based Chalcone Derivatives as Antimicrobial Agents

Title:Synthesis and In Vitro Evaluation of Furan-Based Chalcone Derivatives as Antimicrobial Agents

Volume: 12 Issue: 7

Author(s): Ahmet Ozdemir, Mehlika Dilek Altıntop, Zerrin Canturk and Zafer Asim Kaplancikli

Affiliation:

Keywords: Chalcone, furan, antibacterial activity, anticandidal activity.

Abstract: Some furan-based chalcone derivatives were synthesized via the Claisen-Schmidt condensation of 5-arylfurfural derivatives with 4'-cyanoacetophenone. The synthesized derivatives were investigated for their antimicrobial activity using a broth microdilution assay. Among these compounds, 1-(4-cyanophenyl)-3-[5-(4-nitrophenyl)-2-furyl]-2-propen-1-one (4) can be considered as the most promising antimicrobial agent against Enterococcus faecalis (ATCC 51922) and Candida albicans. Compound 4 showed antimicrobial activity against E. faecalis with a MIC value of 100 µg/mL, whereas chloramphenicol exhibited its antibacterial activity with a MIC value of 200 g/mL. Compound 4 (MIC = 100 µg/mL) was also more effective than ketoconazole (MIC = 200 µg/mL) against C. albicans. Microbiological assay pointed out the importance of p-nitro substituent for antimicrobial activity.

Cite this article as:

Ozdemir Ahmet, Dilek Altıntop Mehlika, Canturk Zerrin and Asim Kaplancikli Zafer, Synthesis and In Vitro Evaluation of Furan-Based Chalcone Derivatives as Antimicrobial Agents, Letters in Drug Design & Discovery 2015; 12 (7) . https://dx.doi.org/10.2174/1570180812999150202112352

DOI https://dx.doi.org/10.2174/1570180812999150202112352	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X