摘要
内质网(ER)对于蛋白质和脂质的合成、折叠和细胞内平衡是非常重要的。内质网功能损伤将会导致内质网应激,这可能会在许多不同的病理状态中发挥重要作用。小热休克蛋白(sHsps)已知在许多组织中广泛的表达。sHsps被发现能调节许多病理和病理生理过程,并且它们被认为是潜在的治疗靶点。最近的研究表明多个sHsps存在于哺乳动物和植物内置网中并在很多细胞过程中对内质网应激提供保护。该机制负责sHsps的细胞保护作用涉及到维持ER稳态。提高sHsps对ER相关的细胞保护作用的了解和特异性针对ER应激信号的分子使得sHsps毒副作用得到改善的有效策略,在发展中对ER功能障碍引起的紊乱的治疗方法中是非常重要的。
关键词: 细胞凋亡,癌症,细胞保护,内质网(ER)应激,小热休克蛋白(sHsps)
Current Molecular Medicine
Title:Small Heat Shock Proteins and the Endoplasmic Reticulum: Potential Attractive Therapeutic Targets?
Volume: 15 Issue: 1
Author(s): L. Zeng, J. Tan, T. Lu, Q. Lei, C. Chen and Z. Hu
Affiliation:
关键词: 细胞凋亡,癌症,细胞保护,内质网(ER)应激,小热休克蛋白(sHsps)
摘要: The endoplasmic reticulum(ER) is crucial for protein and lipid synthesis, folding and cellular homeostasis. Function impairment of ER would induce ER stress, which might play an important role in many different pathological states. Small heat shock proteins (sHsps) are known to be widely expressed throughout many tissues. SHsps are found to regulate many different pathological and pathophysiological processes and they are supposed to be potential therapeutic targets. Recent studies indicate that multiple sHsps localize to the mammalian and plant ER and sHsps confer protection against ER stress in multiple cellular processes. The mechanisms responsible for the cytoprotective effects of sHsps are related to maintaining ER homeostasis. Improved understanding of sHsps-related cytoprotective action on ER and successful strategies which could specifically target components of ER stress signalling responses amelioration of their toxic effects by sHsps is of great importance in the development of therapeutic approach for the disorders induced by dysfunction of ER.
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Cite this article as:
L. Zeng, J. Tan, T. Lu, Q. Lei, C. Chen and Z. Hu , Small Heat Shock Proteins and the Endoplasmic Reticulum: Potential Attractive Therapeutic Targets?, Current Molecular Medicine 2015; 15 (1) . https://dx.doi.org/10.2174/1566524015666150114111745
DOI https://dx.doi.org/10.2174/1566524015666150114111745 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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