摘要
癌症干细胞是细胞内的一个子集拥有自我保持肿瘤、分化和抵抗化放疗的能力。近年来在肝细胞癌(HCC)研究中,支持肝癌干细胞(LCSCs)作为关键肿瘤启动细胞和肿瘤进展的主要因素。目前主要针对LCSCs方法去除LCSC标记的表达,中断的关键LCSCs信号通路、干扰rna或micro-RNA靶点、诱导分化LCSCs、 中断LCSCs药物抗性。然而, 在临床上实施这些方法,LCSCs复杂的基因调控通路是一个重要的障碍。鉴于调停LCSC肿瘤生成路径的深入了解,开发新治疗肝细胞癌的策略和改善临床结果势在必行。
关键词: 药物抗性,变异,肝癌,癌症干细胞, micro-RNA,自我更新,信号通路
Current Gene Therapy
Title:Targeting Cancer Stem Cells as a Therapeutic Approach in Liver Cancer
Volume: 15 Issue: 2
Author(s): Gang Zhou, George Wilson, Jacob George and Liang Qiao
Affiliation:
关键词: 药物抗性,变异,肝癌,癌症干细胞, micro-RNA,自我更新,信号通路
摘要: Cancer stem cells (CSCs) are a subset of cells within tumours that have the ability to selfrenew, differentiate and resist both chemotherapy and radiotherapy. Evidence has emerged in recent years to support liver cancer stem cells (LCSCs) as the key tumour initiating cells and major drivers of tumour progression in hepatocellular carcinoma (HCC). Currently the major approaches to targeting LCSCs are ablating the expression of LCSC markers, disruption of key LCSCs signaling pathways, micro-RNA or siRNA targeting, inducing differentiation of LCSCs and the disruption of chemoresistance of LCSCs. However, complex crosstalk amongst gene regulatory pathways in LCSCs provides a major barrier in implementing these approaches in a clinical setting. Given these findings a deeper understanding of the pathways that mediate LCSC tumourigenesis is imperative for developing new therapeutic strategies for HCC and to improve clinical outcomes.
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Gang Zhou, George Wilson, Jacob George and Liang Qiao , Targeting Cancer Stem Cells as a Therapeutic Approach in Liver Cancer, Current Gene Therapy 2015; 15 (2) . https://dx.doi.org/10.2174/1566523214666141224095938
DOI https://dx.doi.org/10.2174/1566523214666141224095938 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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