肝细胞癌基因治疗的现状,关注基因传递方法

Title:Current Status of Gene Therapy for Hepatocellular Carcinoma, with a Focus on Gene Delivery Approaches

Volume: 15 Issue: 2

Author(s): Xiaoyu Wang, Zongguang Tai, Wei Zhang and Shen Gao

Affiliation:

关键词: 基因治疗，肝癌，靶向性非病毒载体，物理治疗，病毒载体

摘要: Hepatocellular carcinoma (HCC) is a malignancy with high morbidity and mortality rates, especially in East Asia. Gene therapy is a potential approach for treating HCC. An efficient and safe gene delivery method is a crucial factor for HCC gene therapy. In recent years, gene delivery systems, including viral and non-viral gene vectors, bacteria, and physical methods, have undergone substantial development. Among them, various non-viral vectors have been studied widely and in detail because they are relatively safe and have a high capacity. In this review, we focus on current and emerging HCC delivery techniques and address the challenges involved in the use and improvement of non-viral vectors.

Cite this article as:

Xiaoyu Wang, Zongguang Tai, Wei Zhang and Shen Gao , Current Status of Gene Therapy for Hepatocellular Carcinoma, with a Focus on Gene Delivery Approaches, Current Gene Therapy 2015; 15 (2) . https://dx.doi.org/10.2174/1566523214666141224095411