Current Status of Gene Therapy for Hepatocellular Carcinoma, with a Focus on Gene Delivery Approaches

Title:Current Status of Gene Therapy for Hepatocellular Carcinoma, with a Focus on Gene Delivery Approaches

Volume: 15 Issue: 2

Author(s): Xiaoyu Wang, Zongguang Tai, Wei Zhang and Shen Gao

Affiliation:

Keywords: Gene therapy, hepatocellular carcinoma, non-viral vector, physical methods, viral vectors.

Abstract: Hepatocellular carcinoma (HCC) is a malignancy with high morbidity and mortality rates, especially in East Asia. Gene therapy is a potential approach for treating HCC. An efficient and safe gene delivery method is a crucial factor for HCC gene therapy. In recent years, gene delivery systems, including viral and non-viral gene vectors, bacteria, and physical methods, have undergone substantial development. Among them, various non-viral vectors have been studied widely and in detail because they are relatively safe and have a high capacity. In this review, we focus on current and emerging HCC delivery techniques and address the challenges involved in the use and improvement of non-viral vectors.

Cite this article as:

Wang Xiaoyu, Tai Zongguang, Zhang Wei and Gao Shen, Current Status of Gene Therapy for Hepatocellular Carcinoma, with a Focus on Gene Delivery Approaches, Current Gene Therapy 2015; 15 (2) . https://dx.doi.org/10.2174/1566523214666141224095411