Synthesis and Biological Evaluation of 1,5-Naphthyridines as Topoisomerase I Inhibitors. A New Family of Antiproliferative Agents

Title:Synthesis and Biological Evaluation of 1,5-Naphthyridines as Topoisomerase I Inhibitors. A New Family of Antiproliferative Agents

Volume: 14 Issue: 23

Author(s): Concepcion Alonso, Maria Fuertes, Maria Gonzalez, Alicia Rodriguez-Gascon, Gloria Rubiales and Francisco Palacios

Affiliation:

Keywords: Camptothecin, cytotoxicity, heterocycles, inhibitory activity, naphthyridines, topoisomerase I.

Abstract: The synthesis of a variety of phenyl- and indeno-1,5-naphthyridine derivatives as new substrates with anticancer activity is described. Several of the prepared products were addressed to in vitro anticancer screening which indicated that some of them exhibited inhibitory effect of Top1 and antiproliferative activity against human colon cancer cells (COLO 205).

Cite this article as:

Alonso Concepcion, Fuertes Maria, Gonzalez Maria, Rodriguez-Gascon Alicia, Rubiales Gloria and Palacios Francisco, Synthesis and Biological Evaluation of 1,5-Naphthyridines as Topoisomerase I Inhibitors. A New Family of Antiproliferative Agents, Current Topics in Medicinal Chemistry 2014; 14 (23) . https://dx.doi.org/10.2174/1568026614666141215152441