摘要
痴呆是一个与年龄密切相关由于认知下降导致的综合症,可以被认为是一个典型的在老年人中集合生理和病理的且与年龄相关的变化。它包括了的严重的到轻微的认知障碍都存在认知减退和痴呆的中间期。这些症状的发展导致相关的研究和尝试减少痴呆发生的风险因子。他们包括了胰岛素抵抗和高血胰岛素增多、高血压、肥胖、抽烟、沮丧、认知缺乏或者低的教育程度以及缺乏锻炼和不规律的饮食,这些都可被认为是最重要的因子之一。一个可靠的策略用于减低轻度认知障碍和痴呆的爆发可能是使用营养干预。在过去的十年,预测性的数据表明丰富的水果和蔬菜摄入能够改善认知功能和减低神经退行过程风险的发展。对神经退行的保护作用有一部分可能是由于黄酮类物质的摄入,与他的一些健康因素如抗氧化性和抗炎活性、增加神经信号传导和增加代谢功能等相关。本文的目标在于综述科学的研究以显示黄酮类物质的摄入在抵抗前度认知障碍和痴呆的保护作用。
关键词: 抗炎活性,抗氧化性,痴呆,黄酮类,神经退行疾病。
Current Medicinal Chemistry
Title:Flavonoids and Dementia: An Update
Volume: 22 Issue: 8
Author(s): I.E. Orhan, M. Daglia, S.F. Nabavi, M.R. Loizzo, E. Sobarzo-Sanchez and S.M. Nabavi
Affiliation:
关键词: 抗炎活性,抗氧化性,痴呆,黄酮类,神经退行疾病。
摘要: Dementia is a strongly age-related syndrome due to cognitive decline that can be considered a typical example of the combination of physiological and pathological aging-associated changes occurring in old people; it ranges from intact cognition to mild cognitive impairment, which is an intermediate stage of cognitive deterioration, and dementia. The spread of this syndrome has induced to study and try to reduce dementia modifiable risk factors. They include insulin resistance and hyperinsulinaemia, high blood pressure, obesity, smoking, depression, cognitive inactivity or low educational attainment as well as physical inactivity and incorrect diet, which can be considered one of the most important factors. One emerging strategy to decrease the prevalence of mild cognitive impairment and dementia may be the use of nutritional interventions. In the last decade, prospective data have suggested that high fruit and vegetable intakes are related to improved cognitive functions and reduced risks of developing a neurodegenerative process. The protective effects against neurodegeneration could be in part due to the intake of flavonoids that have been associated with several health benefits such as antioxidant and anti-inflammatory activities, increased neuronal signaling, and improved metabolic functions. The present article is aimed at reviewing scientific studies that show the protective effects of flavonoid intake against mild cognitive impairment and dementia.
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Cite this article as:
I.E. Orhan, M. Daglia, S.F. Nabavi, M.R. Loizzo, E. Sobarzo-Sanchez and S.M. Nabavi , Flavonoids and Dementia: An Update, Current Medicinal Chemistry 2015; 22 (8) . https://dx.doi.org/10.2174/0929867322666141212122352
DOI https://dx.doi.org/10.2174/0929867322666141212122352 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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