摘要
在全球女性癌症中,宫颈癌为常见的第三大癌症,每年有275.000人此病而死亡。宫颈癌的发展与由高风险的HPV癌蛋白(E5, E6 and E7) 持续表达引起的细胞循环干扰相关,HPV癌蛋白可以调节宿主基因和胞内microRNAs 的表达。全世界目前约有500万女性被HPV感染 ,他们中的一些人将会发展成浸润性宫颈癌。尽管批准的疗法失败于常规筛选实验,但是其对HPV感染也没有直接作用。鉴于此,宫颈癌的有效治疗仍迫切需要 ,尤其是在超过85%病例致命的发展中国家。本文中,我们综述了目前正在研究的分子靶向疗法,可能会对HPV相关的宫颈非典型增生和宫颈癌的治疗产生重大影响。
关键词: 宫颈癌,HPV,微RNA,分子靶点,疗法
Current Drug Targets
Title:Prospects of Molecularly-Targeted Therapies for Cervical Cancer Treatment
Volume: 16 Issue: 1
Author(s): Antonio Carlos de Freitas, Maria da Conceicao Gomes Leitao and Eliane Campos Coimbra
Affiliation:
关键词: 宫颈癌,HPV,微RNA,分子靶点,疗法
摘要: Cervical cancer is the third most common cancer among women worldwide and is responsible for 275.000 deaths each year. The development of cervical cancer has been linked to cell cycle disturbances caused by persistent expression of high- risk HPV oncoproteins (E5, E6 and E7), which modulate the expression of host genes and cellular microRNAs. An estimated 5 million women throughout the world are currently infected by HPV and several of them will develop invasive cervical cancer. Despite failures in conventional screening tests, approved therapies have no direct effect on HPV infection. In view of this, effective therapy for cervical cancer is still urgently needed, particularly in developing countries where more than 85% of fatal cases occur. In this paper we review the current molecular targeted therapies which are being explored and may have a significant impact on the treatment of HPV- related cervical dysplasia and carcinoma.
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Antonio Carlos de Freitas, Maria da Conceicao Gomes Leitao and Eliane Campos Coimbra , Prospects of Molecularly-Targeted Therapies for Cervical Cancer Treatment, Current Drug Targets 2015; 16 (1) . https://dx.doi.org/10.2174/1389450116666141205150942
DOI https://dx.doi.org/10.2174/1389450116666141205150942 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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