Synthesis and Evaluation of Indole Based Molecules for Treatment of Oxidative Stress Related Diseases

Title:Synthesis and Evaluation of Indole Based Molecules for Treatment of Oxidative Stress Related Diseases

Volume: 14 Issue: 22

Author(s): Francesca Aiello and Giuseppe Valacchi

Affiliation:

Keywords: Alzheimer, Antioxidants, Cancer, Cardiovascular diseases, Enzymes, Reactive oxygen species.

Abstract: The chemical versatility of the indole nucleus still inspires the pharmaceutical research to develop innovative suitable indole based drugs. The present work is an overview of the use and application of indole molecule based derivatives, as possible treatment in the main Oxidative Stress related diseases, such as cardiovascular, neurological, and cancer. The indole nucleus is a particular class of reducers, very efficient when bearing aliphatic substitutions in position 3, like that found in tryptophan (Trp). The principal chemical modifications carried out on the indole nucleus, were focused to obtain orally active drugs for a simpler delivery to the patients.

Cite this article as:

Aiello Francesca and Valacchi Giuseppe, Synthesis and Evaluation of Indole Based Molecules for Treatment of Oxidative Stress Related Diseases, Current Topics in Medicinal Chemistry 2014; 14 (22) . https://dx.doi.org/10.2174/1568026614666141203142926