Abstract
The pigment epithelium-derived factor (PEDF) is a non-inhibitory serpin, which is expressed mainly in the eye, but was also reported to be present in the adult human brain, spinal cord and plasma. It is characterized as a neurotrophic/ neuroprotective factor and one of the most potent natural inhibitors of angiogenesis in the eye, where it plays a physiological regulatory role in retinal angiogenesis. In this review we describe the expression, structure-function relationships, biological activities and regulation of PEDF. In addition, we emphasize our recent findings on the role of extracellular phosphorylation in PEDF activity, and show that the neurotrophic and antiangiogenic functions of PEDF are highly influenced by its phosphorylation state. Hence, phosphorylation of PEDF may be one of the modes that determine its specific physiological outcome.
Keywords: PEDF, antiangiogenesis, neurotrophic factor, extracellular phosphorylation, protein kinases
Current Genomics
Title: The Neurotrophic and Antiangiogenic Functions of PEDF: A Reflection of its Variable Phosphorylation States
Volume: 6 Issue: 8
Author(s): Galia Maik-Rachline and Rony Seger
Affiliation:
Keywords: PEDF, antiangiogenesis, neurotrophic factor, extracellular phosphorylation, protein kinases
Abstract: The pigment epithelium-derived factor (PEDF) is a non-inhibitory serpin, which is expressed mainly in the eye, but was also reported to be present in the adult human brain, spinal cord and plasma. It is characterized as a neurotrophic/ neuroprotective factor and one of the most potent natural inhibitors of angiogenesis in the eye, where it plays a physiological regulatory role in retinal angiogenesis. In this review we describe the expression, structure-function relationships, biological activities and regulation of PEDF. In addition, we emphasize our recent findings on the role of extracellular phosphorylation in PEDF activity, and show that the neurotrophic and antiangiogenic functions of PEDF are highly influenced by its phosphorylation state. Hence, phosphorylation of PEDF may be one of the modes that determine its specific physiological outcome.
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Cite this article as:
Maik-Rachline Galia and Seger Rony, The Neurotrophic and Antiangiogenic Functions of PEDF: A Reflection of its Variable Phosphorylation States, Current Genomics 2005; 6 (8) . https://dx.doi.org/10.2174/138920205775811425
DOI https://dx.doi.org/10.2174/138920205775811425 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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