阿尔茨海默病发病机制中的最小（蓝斑）抵抗

Title:Locus (Coeruleus) Minoris Resistentiae in Pathogenesis of Alzheimer’s Disease

Volume: 11 Issue: 10

Author(s): Boris Mravec, Katarina Lejavova and Veronika Cubinkova

Affiliation:

关键词: 阿尔茨海默病，血脑屏障，蓝斑，神经炎症，适应性，tau蛋白

摘要: Alzheimer’s disease (AD) represents the most prevalent form of dementia in the elderly. However, the pathological mechanisms underlying the development and progression of AD are only partially understood. To date, the accumulated clinical and experimental evidence indicate that the locus coeruleus (LC), the main source of brain’s norepinephrine, represents “the epicenter” of pathology leading to the development of AD. Evidence for this includes observations that neurons of the LC modulate several processes that are altered in brains of AD patients, including synaptic plasticity, neuroinflammation, neuronal metabolism, and blood-brain-barrier permeability. Moreover, the LC undergoes significant degeneration in the brains of AD patients and is considered a source of the prion-like spreading of tau pathology to forebrain structures innervated by the noradrenergic neurons of the LC. Furthermore, lesions of the LC exaggerate AD-related pathology, while augmentation of the brain’s noradrenergic neurotransmission reduces both neuroinflammation and cognitive decline. We hypothesize that better understanding the role of the LC neurons in AD pathogenesis may lead to development of new strategies for the treatment of AD.

Cite this article as:

Boris Mravec, Katarina Lejavova and Cubinkova Veronika, Locus (Coeruleus) Minoris Resistentiae in Pathogenesis of Alzheimer’s Disease, Current Alzheimer Research 2014; 11 (10) . https://dx.doi.org/10.2174/1567205011666141107130505