Expeditious Synthesis of bis-(α-hydroxyalkyl)phosphinic Acid Using N-O-bis (trimethylsilyl)acetamide (BSA)

Chelliah      Selvam; Francine      Acher

doi:10.2174/1570179411999141106101117

Abstract

Highly efficient, synthetic procedure for bis-(α-hydroxyalkyl)phosphinic acids is described using N-O-bis( trimethylsilyl)acetamide (BSA). Various substituted aldehydes undergo the addition of hypophosphorous acid in good to excellent yields. Operational simplicity, high yield and shorter reaction time are the key features associated with this protocol.

Keywords: α-hydroxyphosphinic acid, Hypophosphorous acid, N-O-bis(trimethylsilyl)acetamide, Phosphinic acids, P-alkylation.

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Current Organic Synthesis

Title:Expeditious Synthesis of bis-(α-hydroxyalkyl)phosphinic Acid Using N-O-bis (trimethylsilyl)acetamide (BSA)

Volume: 12 Issue: 2

Author(s): Chelliah Selvam and Francine Acher

Affiliation:

Keywords: α-hydroxyphosphinic acid, Hypophosphorous acid, N-O-bis(trimethylsilyl)acetamide, Phosphinic acids, P-alkylation.

Abstract: Highly efficient, synthetic procedure for bis-(α-hydroxyalkyl)phosphinic acids is described using N-O-bis( trimethylsilyl)acetamide (BSA). Various substituted aldehydes undergo the addition of hypophosphorous acid in good to excellent yields. Operational simplicity, high yield and shorter reaction time are the key features associated with this protocol.

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Selvam Chelliah and Acher Francine, Expeditious Synthesis of bis-(α-hydroxyalkyl)phosphinic Acid Using N-O-bis (trimethylsilyl)acetamide (BSA), Current Organic Synthesis 2015; 12 (2) . https://dx.doi.org/10.2174/1570179411999141106101117

DOI https://dx.doi.org/10.2174/1570179411999141106101117	Print ISSN 1570-1794
Publisher Name Bentham Science Publisher	Online ISSN 1875-6271